60027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1465529..1466876 Replicon chromosome
Accession NZ_CP014048
Organism Vibrio vulnificus strain FDAARGOS_119

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag AL549_RS06145 Protein ID WP_061058143.1
Coordinates 1465529..1466470 (-) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A3Q0KXE1
Locus tag AL549_RS06150 Protein ID WP_011081161.1
Coordinates 1466472..1466876 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL549_RS06140 1463588..1464955 - 1368 WP_061058142.1 hypothetical protein -
AL549_RS06145 1465529..1466470 - 942 WP_061058143.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
AL549_RS06150 1466472..1466876 - 405 WP_011081161.1 hypothetical protein Antitoxin
AL549_RS06155 1467209..1468969 + 1761 WP_061058144.1 ABC transporter ATP-binding protein/permease -
AL549_RS06160 1469025..1469789 - 765 WP_045619593.1 nucleotidyltransferase domain-containing protein -
AL549_RS23805 1470108..1470302 + 195 WP_123776202.1 hypothetical protein -
AL549_RS06165 1470289..1471035 - 747 WP_026050861.1 carbon-nitrogen hydrolase family protein -
AL549_RS06170 1471225..1471683 - 459 WP_061058145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 36103.53 Da        Isoelectric Point: 5.3076

>T60027 WP_061058143.1 NZ_CP014048:c1466470-1465529 [Vibrio vulnificus]
MNALKQQFLEVSDALELGNPAIIEKDFWVVALLAELAKVSPEYHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRAKKKGVRKAWVNEIEQAIIHSERFTVETRSVRDEYRYVEFELRYPQQFSQVPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPHEVSSFDCVSVYATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCITKLTMSEFNSIDGLFKAVL
EEDIARFGNQHAEFVANPKQELQLGLKELEENPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T60027 NZ_CP014048:c1466470-1465529 [Vibrio vulnificus]
ATGAACGCACTAAAACAACAATTTCTTGAGGTTTCCGACGCGCTTGAGCTCGGAAATCCTGCCATCATTGAAAAAGATTT
CTGGGTCGTCGCCTTACTTGCCGAGCTAGCAAAAGTTTCTCCTGAATATCATCAAATGGTCTTTTCCGGCGGCACGGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCAAGCGTTTGATGAA
CTGAGTCGAGCAAAAAAGAAAGGCGTTAGAAAGGCATGGGTTAACGAGATTGAACAGGCGATCATTCATTCAGAACGATT
TACCGTTGAAACGCGATCTGTGCGAGATGAGTACCGTTACGTTGAGTTTGAACTCAGATATCCGCAACAGTTTAGTCAAG
TTCCCTGTCTTCGTCCCATCATTAAGTTAGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCACTGGTTGCAGAGTTGTACCAACAACCGCACGAAGTGAGTTCATTTGATTGCGTCTCTGTCTATGCCACATTGGTTGA
AAAAATCATTTCGATGCTGCGCCGTACAATGTCGGTAAAACGCAATACGGAGCGAAGCGATGATGTTGCTCTAGTTCGCC
ATATCTACGATGTGCATTGCATAACAAAGCTCACAATGTCTGAATTCAACTCGATTGACGGCCTTTTCAAAGCGGTATTG
GAAGAAGATATTGCCCGCTTTGGCAATCAACATGCAGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTCAA
AGAGCTTGAGGAAAATCCCATTTTCCGCCAACGTTTTCAGGACTTTGTCACACCAATGGTGTTTAACACTGAGCCCCATG
ATTTTGATACCTGCTTTGCCTCATTCAAGCGAATTGCAGCGTCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15175.47 Da        Isoelectric Point: 10.6526

>AT60027 WP_011081161.1 NZ_CP014048:c1466876-1466472 [Vibrio vulnificus]
MTAVDRIYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALVRE
ILKMKGVDFEMDSLSQQSLSGASTQIPSSVHYSWNPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT60027 NZ_CP014048:c1466876-1466472 [Vibrio vulnificus]
ATGACAGCAGTAGACCGCATTTATCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGACGGATT
TGCAAGTTACGACCAAATAGGTCGGGCATTGAGGCAGCTTGTACAGCAAGGGGAGCTAATGAAGCTTGGCTATGGTTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGTAAGCCTATGCCTACCAATCCAGGTGGTACCGATGCTCTTGTGCGTGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAAATGGATAGTCTATCGCAACAAAGTCTTTCAGGTGCGAGTACCCAAATTCC
ATCCTCTGTTCACTATTCATGGAACCCAAAACAGTTTAATCGCAAACTGGTGGTTGGTAGCCGTGTGCTGAACTTGCCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0KXE1

References