Detailed information of TA system TA060026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 133446..134005
• Replicon: chromosome
• Accession: NZ_CP014048
• Organism: Vibrio vulnificus strain FDAARGOS_119

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL549_RS00515
• Protein ID: WP_061057688.1
• Coordinates: 133446..133724 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: AL549_RS00520
• Protein ID: WP_011082348.1
• Coordinates: 133721..134005 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL549_RS00485	128934..130013	+	1080	WP_061057686.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
AL549_RS00490	130143..130658	+	516	WP_045619818.1	lipocalin family protein	-
AL549_RS00495	131728..131985	+	258	WP_061057687.1	hypothetical protein	-
AL549_RS00500	132032..132124	+	93	WP_079720568.1	DUF3265 domain-containing protein	-
AL549_RS00505	132293..132793	+	501	WP_038939959.1	hypothetical protein	-
AL549_RS00510	132803..133057	+	255	Protein_99	hypothetical protein	-
AL549_RS00515	133446..133724	-	279	WP_061057688.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
AL549_RS00520	133721..134005	-	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AL549_RS00525	134223..134831	+	609	WP_011151714.1	hypothetical protein	-
AL549_RS00530	134966..135499	+	534	WP_011151713.1	hypothetical protein	-
AL549_RS00535	135685..135948	+	264	WP_061057689.1	hypothetical protein	-
AL549_RS00540	136026..136526	+	501	WP_061057690.1	hypothetical protein	-
AL549_RS00545	136606..137637	-	1032	WP_011082342.1	L-threonine 3-dehydrogenase	-
AL549_RS00550	137759..138952	-	1194	WP_061057691.1	glycine C-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	132803..134831	2028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10878.57 Da
• Isoelectric Point: 4.2397

>T60026 WP_061057688.1 NZ_CP014048:c133724-133446 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDSILGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T60026 NZ_CP014048:c133724-133446 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCTCGGTCGATTACTCATTATTCCTGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT60026 WP_011082348.1 NZ_CP014048:c134005-133721 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT60026 NZ_CP014048:c134005-133721 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2