Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2250755..2251314 | Replicon | chromosome |
| Accession | NZ_CP014046 | ||
| Organism | Vibrio parahaemolyticus strain FDAARGOS_115 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W573 |
| Locus tag | AL464_RS11985 | Protein ID | WP_005500338.1 |
| Coordinates | 2250755..2251033 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | AL464_RS11990 | Protein ID | WP_005398409.1 |
| Coordinates | 2251030..2251314 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL464_RS11925 | 2246481..2246822 | + | 342 | WP_029807300.1 | hypothetical protein | - |
| AL464_RS11930 | 2246845..2246934 | + | 90 | WP_077345730.1 | DUF3265 domain-containing protein | - |
| AL464_RS11935 | 2247209..2247328 | + | 120 | WP_161795966.1 | DUF3265 domain-containing protein | - |
| AL464_RS11940 | 2247571..2247945 | + | 375 | WP_031823068.1 | SEC-C domain-containing protein | - |
| AL464_RS11945 | 2248101..2248484 | + | 384 | WP_029806841.1 | hypothetical protein | - |
| AL464_RS25535 | 2248640..2248999 | + | 360 | WP_029806843.1 | hypothetical protein | - |
| AL464_RS11960 | 2249138..2249428 | - | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AL464_RS11965 | 2249418..2249666 | - | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| AL464_RS25770 | 2249741..2249809 | + | 69 | WP_074531725.1 | DUF3265 domain-containing protein | - |
| AL464_RS11975 | 2250266..2250619 | + | 354 | WP_017449619.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| AL464_RS25775 | 2250637..2250726 | + | 90 | WP_072828858.1 | DUF3265 domain-containing protein | - |
| AL464_RS11985 | 2250755..2251033 | - | 279 | WP_005500338.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| AL464_RS11990 | 2251030..2251314 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| AL464_RS11995 | 2251581..2251871 | + | 291 | WP_005500341.1 | YkgJ family cysteine cluster protein | - |
| AL464_RS12005 | 2252539..2253689 | + | 1151 | WP_104411426.1 | IS3 family transposase | - |
| AL464_RS12010 | 2253679..2254052 | + | 374 | Protein_2078 | pyridoxamine 5'-phosphate oxidase family protein | - |
| AL464_RS12015 | 2254420..2254866 | - | 447 | WP_021449154.1 | DUF3291 domain-containing protein | - |
| AL464_RS12020 | 2255208..2255669 | + | 462 | WP_005500350.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vpadF | 2209717..2296233 | 86516 | |
| - | inside | Integron | - | - | 2231942..2254185 | 22243 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10878.53 Da Isoelectric Point: 4.2597
>T60025 WP_005500338.1 NZ_CP014046:c2251033-2250755 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T60025 NZ_CP014046:c2251033-2250755 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTGATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGATATTTCGATGATTGTGTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTGATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGATATTTCGATGATTGTGTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT60025 WP_005398409.1 NZ_CP014046:c2251314-2251030 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT60025 NZ_CP014046:c2251314-2251030 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249W573 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |