Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2249138..2249666 Replicon chromosome
Accession NZ_CP014046
Organism Vibrio parahaemolyticus strain FDAARGOS_115

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL464_RS11960 Protein ID WP_005377002.1
Coordinates 2249138..2249428 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL464_RS11965 Protein ID WP_005377003.1
Coordinates 2249418..2249666 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL464_RS11910 2244715..2244843 + 129 WP_077345729.1 DUF3265 domain-containing protein -
AL464_RS11920 2245357..2245869 + 513 WP_029807290.1 hypothetical protein -
AL464_RS11925 2246481..2246822 + 342 WP_029807300.1 hypothetical protein -
AL464_RS11930 2246845..2246934 + 90 WP_077345730.1 DUF3265 domain-containing protein -
AL464_RS11935 2247209..2247328 + 120 WP_161795966.1 DUF3265 domain-containing protein -
AL464_RS11940 2247571..2247945 + 375 WP_031823068.1 SEC-C domain-containing protein -
AL464_RS11945 2248101..2248484 + 384 WP_029806841.1 hypothetical protein -
AL464_RS25535 2248640..2248999 + 360 WP_029806843.1 hypothetical protein -
AL464_RS11960 2249138..2249428 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL464_RS11965 2249418..2249666 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL464_RS25770 2249741..2249809 + 69 WP_074531725.1 DUF3265 domain-containing protein -
AL464_RS11975 2250266..2250619 + 354 WP_017449619.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
AL464_RS25775 2250637..2250726 + 90 WP_072828858.1 DUF3265 domain-containing protein -
AL464_RS11985 2250755..2251033 - 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
AL464_RS11990 2251030..2251314 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AL464_RS11995 2251581..2251871 + 291 WP_005500341.1 YkgJ family cysteine cluster protein -
AL464_RS12005 2252539..2253689 + 1151 WP_104411426.1 IS3 family transposase -
AL464_RS12010 2253679..2254052 + 374 Protein_2078 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF 2209717..2296233 86516
- inside Integron - - 2231942..2254185 22243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60024 WP_005377002.1 NZ_CP014046:c2249428-2249138 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60024 NZ_CP014046:c2249428-2249138 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60024 WP_005377003.1 NZ_CP014046:c2249666-2249418 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60024 NZ_CP014046:c2249666-2249418 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCCTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References