Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2155201..2155748 Replicon chromosome
Accession NZ_CP014046
Organism Vibrio parahaemolyticus strain FDAARGOS_115

Toxin (Protein)


Gene name relE Uniprot ID A0A2K7SRN5
Locus tag AL464_RS10900 Protein ID WP_010448451.1
Coordinates 2155446..2155748 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag AL464_RS10895 Protein ID WP_005448240.1
Coordinates 2155201..2155458 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL464_RS25750 2150562..2150654 + 93 Protein_1872 DUF3265 domain-containing protein -
AL464_RS10845 2150684..2151256 + 573 WP_025639178.1 hypothetical protein -
AL464_RS10850 2151382..2151474 + 93 WP_077345722.1 DUF3265 domain-containing protein -
AL464_RS10855 2151995..2152084 + 90 WP_072829120.1 DUF3265 domain-containing protein -
AL464_RS10860 2152115..2152726 + 612 WP_029807124.1 hypothetical protein -
AL464_RS10865 2152760..2152849 + 90 WP_077345720.1 DUF3265 domain-containing protein -
AL464_RS10870 2152866..2153495 + 630 WP_029807123.1 hypothetical protein -
AL464_RS10880 2154158..2154469 + 312 WP_017420651.1 antibiotic biosynthesis monooxygenase -
AL464_RS10885 2154460..2154627 + 168 WP_104411421.1 DUF3265 domain-containing protein -
AL464_RS10890 2154645..2155010 + 366 WP_029807180.1 hypothetical protein -
AL464_RS10895 2155201..2155458 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL464_RS10900 2155446..2155748 + 303 WP_010448451.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL464_RS10905 2155784..2155876 + 93 WP_072612521.1 DUF3265 domain-containing protein -
AL464_RS10910 2155947..2156234 + 288 WP_029807151.1 hypothetical protein -
AL464_RS10915 2156401..2157039 + 639 WP_077345721.1 hypothetical protein -
AL464_RS10925 2157522..2157614 + 93 WP_005494807.1 DUF3265 domain-containing protein -
AL464_RS10930 2157640..2158401 + 762 WP_029807115.1 hypothetical protein -
AL464_RS10935 2158584..2159015 + 432 WP_029807113.1 hypothetical protein -
AL464_RS10940 2159211..2160167 + 957 WP_029807210.1 hypothetical protein -
AL464_RS10945 2160193..2160285 + 93 WP_010448843.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2145778..2221681 75903


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11625.52 Da        Isoelectric Point: 5.1765

>T60023 WP_010448451.1 NZ_CP014046:2155446-2155748 [Vibrio parahaemolyticus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLGKQ

Download         Length: 303 bp

>T60023 NZ_CP014046:2155446-2155748 [Vibrio parahaemolyticus]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT60023 WP_005448240.1 NZ_CP014046:2155201-2155458 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT60023 NZ_CP014046:2155201-2155458 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTTGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References