Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1368590..1369118 Replicon chromosome
Accession NZ_CP014045
Organism Vibrio alginolyticus strain FDAARGOS_114

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL545_RS14995 Protein ID WP_005377002.1
Coordinates 1368590..1368880 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL545_RS15000 Protein ID WP_005377003.1
Coordinates 1368870..1369118 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL545_RS14950 1364276..1364932 + 657 WP_017822040.1 quinolone resistance pentapeptide repeat protein QnrVC10 -
AL545_RS14960 1365147..1365368 + 222 Protein_1214 transposase -
AL545_RS14965 1365452..1366303 + 852 WP_021033953.1 IS3 family transposase -
AL545_RS14970 1366375..1366806 + 432 WP_005386969.1 DUF1851 domain-containing protein -
AL545_RS24635 1366821..1366913 + 93 WP_112492745.1 DUF3265 domain-containing protein -
AL545_RS14985 1367462..1367683 + 222 Protein_1218 transposase -
AL545_RS14990 1367767..1368549 + 783 WP_021033952.1 IS3 family transposase -
AL545_RS14995 1368590..1368880 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL545_RS15000 1368870..1369118 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL545_RS15005 1369838..1370095 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL545_RS15010 1370083..1370385 + 303 WP_017822001.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL545_RS15015 1370421..1370513 + 93 WP_017822002.1 DUF3265 domain-containing protein -
AL545_RS15025 1371033..1371446 + 414 WP_017822003.1 hypothetical protein -
AL545_RS15030 1371668..1372126 + 459 WP_021033947.1 hypothetical protein -
AL545_RS15035 1372123..1372233 + 111 WP_017822004.1 DUF3265 domain-containing protein -
AL545_RS15040 1372640..1372783 + 144 WP_192943943.1 DUF3265 domain-containing protein -
AL545_RS15045 1372823..1373242 + 420 WP_017822044.1 GNAT family N-acetyltransferase -
AL545_RS15060 1373845..1373922 + 78 WP_080659275.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC6 - 1326791..1398646 71855
- inside Integron - - 1327308..1395912 68604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60021 WP_005377002.1 NZ_CP014045:c1368880-1368590 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60021 NZ_CP014045:c1368880-1368590 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60021 WP_005377003.1 NZ_CP014045:c1369118-1368870 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60021 NZ_CP014045:c1369118-1368870 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTGCCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTGGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References