Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1348385..1348944 Replicon chromosome
Accession NZ_CP014045
Organism Vibrio alginolyticus strain FDAARGOS_114

Toxin (Protein)


Gene name relE Uniprot ID A0A2I3C6F2
Locus tag AL545_RS14770 Protein ID WP_005377065.1
Coordinates 1348385..1348663 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I3C6F3
Locus tag AL545_RS14775 Protein ID WP_005487956.1
Coordinates 1348660..1348944 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL545_RS14715 1343910..1344317 + 408 WP_017822010.1 hypothetical protein -
AL545_RS14720 1344346..1344435 + 90 WP_080666459.1 DUF3265 domain-containing protein -
AL545_RS14725 1344462..1344734 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
AL545_RS14730 1344745..1344855 + 111 WP_080666457.1 DUF3265 domain-containing protein -
AL545_RS14740 1345414..1345923 + 510 WP_017822011.1 hypothetical protein -
AL545_RS14745 1345877..1346029 + 153 WP_078236020.1 DUF3265 domain-containing protein -
AL545_RS14755 1346607..1347296 + 690 WP_017822012.1 hypothetical protein -
AL545_RS14760 1347318..1347410 + 93 WP_017822013.1 DUF3265 domain-containing protein -
AL545_RS14765 1347919..1348239 + 321 WP_017820438.1 hypothetical protein -
AL545_RS14770 1348385..1348663 - 279 WP_005377065.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AL545_RS14775 1348660..1348944 - 285 WP_005487956.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AL545_RS14780 1349139..1349411 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
AL545_RS14785 1349422..1349532 + 111 WP_080666457.1 DUF3265 domain-containing protein -
AL545_RS14790 1349560..1349901 + 342 WP_021033958.1 hypothetical protein -
AL545_RS14795 1349868..1350008 + 141 WP_080659271.1 DUF3265 domain-containing protein -
AL545_RS14800 1350036..1350395 + 360 WP_021033957.1 hypothetical protein -
AL545_RS14805 1350392..1350502 + 111 WP_017822022.1 DUF3265 domain-containing protein -
AL545_RS14810 1350690..1351646 + 957 WP_017822019.1 hypothetical protein -
AL545_RS14820 1352218..1352310 + 93 WP_017821981.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC6 - 1326791..1398646 71855
- inside Integron - - 1327308..1395912 68604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T60020 WP_005377065.1 NZ_CP014045:c1348663-1348385 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T60020 NZ_CP014045:c1348663-1348385 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11082.40 Da        Isoelectric Point: 9.2167

>AT60020 WP_005487956.1 NZ_CP014045:c1348944-1348660 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT60020 NZ_CP014045:c1348944-1348660 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I3C6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A2I3C6F3

References