Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1341119..1341647 Replicon chromosome
Accession NZ_CP014045
Organism Vibrio alginolyticus strain FDAARGOS_114

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL545_RS14680 Protein ID WP_005377002.1
Coordinates 1341119..1341409 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL545_RS14685 Protein ID WP_005377003.1
Coordinates 1341399..1341647 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL545_RS14630 1336444..1336536 + 93 WP_017821997.1 DUF3265 domain-containing protein -
AL545_RS14635 1336599..1337534 - 936 WP_017821998.1 hypothetical protein -
AL545_RS14640 1337659..1337751 + 93 WP_017821999.1 DUF3265 domain-containing protein -
AL545_RS14645 1337781..1338314 + 534 WP_017822000.1 cysteine hydrolase -
AL545_RS14655 1339102..1339740 + 639 WP_005483174.1 EcsC family protein -
AL545_RS14660 1339731..1339847 + 117 WP_080659274.1 DUF3265 domain-containing protein -
AL545_RS14665 1339876..1340346 + 471 WP_017822016.1 GNAT family N-acetyltransferase -
AL545_RS14670 1340653..1340982 + 330 WP_017822015.1 hypothetical protein -
AL545_RS14675 1341008..1341100 + 93 WP_017822014.1 DUF3265 domain-containing protein -
AL545_RS14680 1341119..1341409 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL545_RS14685 1341399..1341647 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL545_RS14690 1341842..1342318 + 477 WP_017822005.1 GNAT family N-acetyltransferase -
AL545_RS14695 1342315..1342437 + 123 WP_017822006.1 DUF3265 domain-containing protein -
AL545_RS14700 1342483..1343127 + 645 WP_017822007.1 glutathione S-transferase family protein -
AL545_RS14705 1343142..1343234 + 93 WP_017822008.1 DUF3265 domain-containing protein -
AL545_RS14710 1343198..1343773 + 576 WP_102949757.1 GNAT family N-acetyltransferase -
AL545_RS14715 1343910..1344317 + 408 WP_017822010.1 hypothetical protein -
AL545_RS14720 1344346..1344435 + 90 WP_080666459.1 DUF3265 domain-containing protein -
AL545_RS14725 1344462..1344734 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
AL545_RS14730 1344745..1344855 + 111 WP_080666457.1 DUF3265 domain-containing protein -
AL545_RS14740 1345414..1345923 + 510 WP_017822011.1 hypothetical protein -
AL545_RS14745 1345877..1346029 + 153 WP_078236020.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC6 - 1326791..1398646 71855
- inside Integron - - 1327308..1395912 68604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60019 WP_005377002.1 NZ_CP014045:c1341409-1341119 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60019 NZ_CP014045:c1341409-1341119 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60019 WP_005377003.1 NZ_CP014045:c1341647-1341399 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60019 NZ_CP014045:c1341647-1341399 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTGCCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTGGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References