Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1331439..1331967 Replicon chromosome
Accession NZ_CP014045
Organism Vibrio alginolyticus strain FDAARGOS_114

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL545_RS14575 Protein ID WP_005377002.1
Coordinates 1331439..1331729 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL545_RS14580 Protein ID WP_005377003.1
Coordinates 1331719..1331967 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL545_RS14535 1326791..1327264 + 474 WP_017820440.1 DUF2947 domain-containing protein -
AL545_RS14540 1327308..1328270 - 963 WP_017636093.1 integron integrase -
AL545_RS14550 1328510..1329052 + 543 WP_017820439.1 GNAT family N-acetyltransferase -
AL545_RS24570 1329081..1329170 + 90 Protein_1140 DUF3265 domain-containing protein -
AL545_RS14555 1329201..1329521 + 321 WP_017820438.1 hypothetical protein -
AL545_RS14560 1329678..1330097 + 420 WP_017822044.1 GNAT family N-acetyltransferase -
AL545_RS14565 1330311..1330532 + 222 Protein_1143 transposase -
AL545_RS14570 1330616..1331398 + 783 WP_021033952.1 IS3 family transposase -
AL545_RS14575 1331439..1331729 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL545_RS14580 1331719..1331967 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL545_RS14585 1332171..1332776 + 606 WP_017822041.1 hypothetical protein -
AL545_RS14595 1333757..1333900 + 144 WP_192943943.1 DUF3265 domain-containing protein -
AL545_RS14600 1333931..1334752 + 822 WP_017821991.1 DUF2002 family protein -
AL545_RS14605 1334867..1335166 + 300 WP_017821992.1 hypothetical protein -
AL545_RS14610 1335163..1335285 + 123 WP_017821993.1 DUF3265 domain-containing protein -
AL545_RS14615 1335364..1335687 - 324 WP_102949758.1 hypothetical protein -
AL545_RS14620 1335774..1335905 + 132 WP_010448899.1 DUF3265 domain-containing protein -
AL545_RS14625 1335934..1336416 + 483 WP_017821996.1 DUF2314 domain-containing protein -
AL545_RS14630 1336444..1336536 + 93 WP_017821997.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC6 - 1326791..1398646 71855
- inside Integron - - 1327308..1395912 68604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60018 WP_005377002.1 NZ_CP014045:c1331729-1331439 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60018 NZ_CP014045:c1331729-1331439 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60018 WP_005377003.1 NZ_CP014045:c1331967-1331719 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60018 NZ_CP014045:c1331967-1331719 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTGCCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTGGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References