Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1209593..1210140 Replicon chromosome
Accession NZ_CP014042
Organism Vibrio mimicus strain FDAARGOS_112

Toxin (Protein)


Gene name relE Uniprot ID A0A099LYZ4
Locus tag AL543_RS06140 Protein ID WP_000852547.1
Coordinates 1209593..1209895 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B5V2P5
Locus tag AL543_RS06145 Protein ID WP_000861988.1
Coordinates 1209883..1210140 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL543_RS06080 1205216..1205416 - 201 WP_104408352.1 DUF3265 domain-containing protein -
AL543_RS06085 1205434..1205793 - 360 WP_061051379.1 VOC family protein -
AL543_RS06090 1206078..1206311 - 234 WP_081096082.1 DUF3709 domain-containing protein -
AL543_RS21530 1206332..1206537 - 206 Protein_1172 DUF3709 domain-containing protein -
AL543_RS21535 1206585..1206785 - 201 WP_025630366.1 hypothetical protein -
AL543_RS06100 1207244..1207591 - 348 WP_017036770.1 DUF3024 domain-containing protein -
AL543_RS06105 1207648..1207794 - 147 WP_081096124.1 DUF3265 domain-containing protein -
AL543_RS06110 1207799..1208383 - 585 WP_188318526.1 DUF3265 domain-containing protein -
AL543_RS06125 1208847..1209116 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin -
AL543_RS06130 1209109..1209363 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
AL543_RS06140 1209593..1209895 - 303 WP_000852547.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL543_RS06145 1209883..1210140 - 258 WP_000861988.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL543_RS06150 1210211..1210342 - 132 WP_081096090.1 DUF3265 domain-containing protein -
AL543_RS06155 1210389..1210634 + 246 WP_017420672.1 type II toxin-antitoxin system CcdA family antitoxin -
AL543_RS06160 1210634..1210951 + 318 WP_017420671.1 CcdB family protein -
AL543_RS06165 1210843..1211070 - 228 Protein_1184 DUF3265 domain-containing protein -
AL543_RS06170 1211067..1211426 - 360 WP_061051379.1 VOC family protein -
AL543_RS06175 1211413..1211580 - 168 WP_208620276.1 DUF3265 domain-containing protein -
AL543_RS06185 1212253..1212405 - 153 WP_161803584.1 DUF3709 domain-containing protein -
AL543_RS06190 1212566..1212694 - 129 WP_072605992.1 DUF3265 domain-containing protein -
AL543_RS06195 1212699..1213163 - 465 WP_061051370.1 ASCH domain-containing protein -
AL543_RS06200 1213312..1214118 - 807 WP_061051380.1 GIY-YIG nuclease family protein -
AL543_RS06205 1214314..1214496 - 183 WP_061051381.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086679..1234651 147972
- inside Integron - - 1108123..1230683 122560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11610.46 Da        Isoelectric Point: 4.8951

>T60017 WP_000852547.1 NZ_CP014042:c1209895-1209593 [Vibrio mimicus]
MAEVIWTEPALSDLNDIAEYIALENVVAAKQLVQAIFSKVERLEVFPESGRIPPELEHLSYREVVANPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSRQ

Download         Length: 303 bp

>T60017 NZ_CP014042:c1209895-1209593 [Vibrio mimicus]
ATGGCTGAAGTAATTTGGACTGAACCGGCGCTATCTGACCTAAATGATATCGCTGAGTACATCGCGCTTGAAAATGTCGT
GGCTGCAAAGCAACTGGTTCAAGCGATCTTCTCAAAAGTCGAACGTCTAGAAGTTTTCCCAGAGTCAGGTCGTATTCCGC
CAGAATTAGAGCATTTGAGTTATCGTGAAGTTGTAGCAAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAGGTA
TTTATACTGTTTGTTATGCGCGCCGAGAGAGATTTGCGTAAGTTCTTGTTAAGTAGACAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9575.08 Da        Isoelectric Point: 7.3177

>AT60017 WP_000861988.1 NZ_CP014042:c1210140-1209883 [Vibrio mimicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERAIADGKVVGHNEAKDKM
SKWLK

Download         Length: 258 bp

>AT60017 NZ_CP014042:c1210140-1209883 [Vibrio mimicus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGGCAAGCAACCAAGATCCTAGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACGGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCCA
TTCTCGAAGGTATTGCACGAGGTGAACGCGCAATAGCTGACGGAAAGGTTGTTGGTCACAATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A099LYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5V2P5

References