Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1208847..1209363 Replicon chromosome
Accession NZ_CP014042
Organism Vibrio mimicus strain FDAARGOS_112

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag AL543_RS06125 Protein ID WP_005464459.1
Coordinates 1208847..1209116 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag AL543_RS06130 Protein ID WP_005483180.1
Coordinates 1209109..1209363 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL543_RS06070 1204124..1204411 - 288 WP_061051378.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL543_RS06075 1204408..1204689 - 282 WP_000086650.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL543_RS06080 1205216..1205416 - 201 WP_104408352.1 DUF3265 domain-containing protein -
AL543_RS06085 1205434..1205793 - 360 WP_061051379.1 VOC family protein -
AL543_RS06090 1206078..1206311 - 234 WP_081096082.1 DUF3709 domain-containing protein -
AL543_RS21530 1206332..1206537 - 206 Protein_1172 DUF3709 domain-containing protein -
AL543_RS21535 1206585..1206785 - 201 WP_025630366.1 hypothetical protein -
AL543_RS06100 1207244..1207591 - 348 WP_017036770.1 DUF3024 domain-containing protein -
AL543_RS06105 1207648..1207794 - 147 WP_081096124.1 DUF3265 domain-containing protein -
AL543_RS06110 1207799..1208383 - 585 WP_188318526.1 DUF3265 domain-containing protein -
AL543_RS06125 1208847..1209116 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
AL543_RS06130 1209109..1209363 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AL543_RS06140 1209593..1209895 - 303 WP_000852547.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL543_RS06145 1209883..1210140 - 258 WP_000861988.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL543_RS06150 1210211..1210342 - 132 WP_081096090.1 DUF3265 domain-containing protein -
AL543_RS06155 1210389..1210634 + 246 WP_017420672.1 type II toxin-antitoxin system CcdA family antitoxin -
AL543_RS06160 1210634..1210951 + 318 WP_017420671.1 CcdB family protein -
AL543_RS06165 1210843..1211070 - 228 Protein_1184 DUF3265 domain-containing protein -
AL543_RS06170 1211067..1211426 - 360 WP_061051379.1 VOC family protein -
AL543_RS06175 1211413..1211580 - 168 WP_208620276.1 DUF3265 domain-containing protein -
AL543_RS06185 1212253..1212405 - 153 WP_161803584.1 DUF3709 domain-containing protein -
AL543_RS06190 1212566..1212694 - 129 WP_072605992.1 DUF3265 domain-containing protein -
AL543_RS06195 1212699..1213163 - 465 WP_061051370.1 ASCH domain-containing protein -
AL543_RS06200 1213312..1214118 - 807 WP_061051380.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086679..1234651 147972
- inside Integron - - 1108123..1230683 122560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T60016 WP_005464459.1 NZ_CP014042:c1209116-1208847 [Vibrio mimicus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T60016 NZ_CP014042:c1209116-1208847 [Vibrio mimicus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGTTCTCCATTTGAGGGCATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAGGCCATA
ACGATAATCTCGTGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT60016 WP_005483180.1 NZ_CP014042:c1209363-1209109 [Vibrio mimicus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT60016 NZ_CP014042:c1209363-1209109 [Vibrio mimicus]
ATGAGAATCGTATCTTTTACTGAAGCAAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAGGATGCAGTAGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References