Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1204124..1204689 | Replicon | chromosome |
| Accession | NZ_CP014042 | ||
| Organism | Vibrio mimicus strain FDAARGOS_112 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | AL543_RS06070 | Protein ID | WP_061051378.1 |
| Coordinates | 1204124..1204411 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | W9USL4 |
| Locus tag | AL543_RS06075 | Protein ID | WP_000086650.1 |
| Coordinates | 1204408..1204689 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL543_RS06040 | 1200483..1201442 | + | 960 | WP_042988413.1 | IS30 family transposase | - |
| AL543_RS06045 | 1201473..1201733 | - | 261 | WP_061051486.1 | hypothetical protein | - |
| AL543_RS21525 | 1202021..1202098 | - | 78 | WP_123772164.1 | hypothetical protein | - |
| AL543_RS06050 | 1202136..1202438 | - | 303 | WP_038969944.1 | hypothetical protein | - |
| AL543_RS06055 | 1202586..1203188 | - | 603 | WP_123772162.1 | hypothetical protein | - |
| AL543_RS06060 | 1203456..1203698 | + | 243 | WP_017019247.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| AL543_RS06065 | 1203695..1203994 | + | 300 | WP_061051377.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AL543_RS06070 | 1204124..1204411 | - | 288 | WP_061051378.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL543_RS06075 | 1204408..1204689 | - | 282 | WP_000086650.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL543_RS06080 | 1205216..1205416 | - | 201 | WP_104408352.1 | DUF3265 domain-containing protein | - |
| AL543_RS06085 | 1205434..1205793 | - | 360 | WP_061051379.1 | VOC family protein | - |
| AL543_RS06090 | 1206078..1206311 | - | 234 | WP_081096082.1 | DUF3709 domain-containing protein | - |
| AL543_RS21530 | 1206332..1206537 | - | 206 | Protein_1172 | DUF3709 domain-containing protein | - |
| AL543_RS21535 | 1206585..1206785 | - | 201 | WP_025630366.1 | hypothetical protein | - |
| AL543_RS06100 | 1207244..1207591 | - | 348 | WP_017036770.1 | DUF3024 domain-containing protein | - |
| AL543_RS06105 | 1207648..1207794 | - | 147 | WP_081096124.1 | DUF3265 domain-containing protein | - |
| AL543_RS06110 | 1207799..1208383 | - | 585 | WP_188318526.1 | DUF3265 domain-containing protein | - |
| AL543_RS06125 | 1208847..1209116 | - | 270 | WP_005464459.1 | Txe/YoeB family addiction module toxin | - |
| AL543_RS06130 | 1209109..1209363 | - | 255 | WP_005483180.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1086679..1234651 | 147972 | |
| - | inside | Integron | - | - | 1108123..1230683 | 122560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10961.77 Da Isoelectric Point: 5.6096
>T60015 WP_061051378.1 NZ_CP014042:c1204411-1204124 [Vibrio mimicus]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREMIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREMIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T60015 NZ_CP014042:c1204411-1204124 [Vibrio mimicus]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTTGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCAG
AAATGCCTCATACAAACTATCGTGAAATGATTTTTGGCCATTACCGCATTATTTATAGTTTGGGCCTCGAAATACGTGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTTGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCAG
AAATGCCTCATACAAACTATCGTGAAATGATTTTTGGCCATTACCGCATTATTTATAGTTTGGGCCTCGAAATACGTGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10347.90 Da Isoelectric Point: 5.1548
>AT60015 WP_000086650.1 NZ_CP014042:c1204689-1204408 [Vibrio mimicus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK
Download Length: 282 bp
>AT60015 NZ_CP014042:c1204689-1204408 [Vibrio mimicus]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCGGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGCCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCGGGTTTAGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGCCGTATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCGGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGCCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCGGGTTTAGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGCCGTATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|