Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 1192028..1192599 Replicon chromosome
Accession NZ_CP014042
Organism Vibrio mimicus strain FDAARGOS_112

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag AL543_RS05965 Protein ID WP_000351248.1
Coordinates 1192028..1192429 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag AL543_RS05970 Protein ID WP_001080654.1
Coordinates 1192429..1192599 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL543_RS05910 1187314..1187679 - 366 WP_061051366.1 hypothetical protein -
AL543_RS05915 1187846..1188205 - 360 WP_061051367.1 VOC family protein -
AL543_RS05920 1188359..1188856 - 498 WP_061051368.1 GNAT family N-acetyltransferase -
AL543_RS05925 1189099..1189335 + 237 WP_000792784.1 ST-I family heat-stable enterotoxin -
AL543_RS21665 1189395..1189538 - 144 Protein_1140 DUF3265 domain-containing protein -
AL543_RS05935 1189514..1189987 - 474 WP_061051369.1 GNAT family N-acetyltransferase -
AL543_RS05940 1190269..1190502 - 234 WP_081096058.1 DUF3709 domain-containing protein -
AL543_RS21520 1190523..1190684 - 162 Protein_1143 DUF3709 domain-containing protein -
AL543_RS05945 1190793..1191140 - 348 WP_033930501.1 DUF3024 domain-containing protein -
AL543_RS05955 1191339..1191875 - 537 WP_061051318.1 GNAT family N-acetyltransferase -
AL543_RS05960 1191915..1192058 - 144 WP_167389953.1 DUF3265 domain-containing protein -
AL543_RS05965 1192028..1192429 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AL543_RS05970 1192429..1192599 - 171 WP_001080654.1 hypothetical protein Antitoxin
AL543_RS05975 1192632..1192781 - 150 WP_081096121.1 DUF3265 domain-containing protein -
AL543_RS05980 1192786..1193250 - 465 WP_061051370.1 ASCH domain-containing protein -
AL543_RS05985 1193457..1193702 + 246 WP_061051371.1 type II toxin-antitoxin system CcdA family antitoxin -
AL543_RS05990 1193702..1194019 + 318 WP_061051372.1 CcdB family protein -
AL543_RS05995 1194137..1194553 - 417 WP_061051373.1 hypothetical protein -
AL543_RS06000 1194718..1195551 - 834 WP_061051374.1 DUF2971 domain-containing protein -
AL543_RS06005 1195696..1196112 - 417 WP_061051373.1 hypothetical protein -
AL543_RS06010 1196130..1196270 - 141 WP_208620275.1 DUF3265 domain-containing protein -
AL543_RS06020 1196878..1197114 - 237 WP_081096061.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086679..1234651 147972
- inside Integron - - 1108123..1230683 122560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T60013 WP_000351248.1 NZ_CP014042:c1192429-1192028 [Vibrio mimicus]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T60013 NZ_CP014042:c1192429-1192028 [Vibrio mimicus]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAACTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT60013 WP_001080654.1 NZ_CP014042:c1192599-1192429 [Vibrio mimicus]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT60013 NZ_CP014042:c1192599-1192429 [Vibrio mimicus]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References