Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1177153..1177691 | Replicon | chromosome |
| Accession | NZ_CP014042 | ||
| Organism | Vibrio mimicus strain FDAARGOS_112 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | AL543_RS05815 | Protein ID | WP_017420621.1 |
| Coordinates | 1177392..1177691 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0F2HR74 |
| Locus tag | AL543_RS05810 | Protein ID | WP_011080384.1 |
| Coordinates | 1177153..1177395 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL543_RS05755 | 1172345..1172605 | - | 261 | WP_151898470.1 | DUF3709 domain-containing protein | - |
| AL543_RS05760 | 1172875..1173426 | - | 552 | WP_061051359.1 | sugar O-acetyltransferase | - |
| AL543_RS05765 | 1173590..1174429 | - | 840 | WP_055032240.1 | hypothetical protein | - |
| AL543_RS21885 | 1174457..1174567 | - | 111 | WP_082798255.1 | DUF3265 domain-containing protein | - |
| AL543_RS05775 | 1174564..1174881 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| AL543_RS05780 | 1174892..1175179 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AL543_RS05790 | 1175409..1175822 | - | 414 | WP_061051312.1 | VOC family protein | - |
| AL543_RS05800 | 1176107..1176244 | - | 138 | WP_000757220.1 | YHYH domain-containing protein | - |
| AL543_RS05805 | 1176582..1176815 | - | 234 | WP_081096082.1 | DUF3709 domain-containing protein | - |
| AL543_RS21505 | 1176836..1176967 | - | 132 | WP_151190709.1 | DUF3709 domain-containing protein | - |
| AL543_RS05810 | 1177153..1177395 | + | 243 | WP_011080384.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| AL543_RS05815 | 1177392..1177691 | + | 300 | WP_017420621.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL543_RS21890 | 1177699..1177791 | - | 93 | WP_208620269.1 | DUF3265 domain-containing protein | - |
| AL543_RS05825 | 1177915..1178268 | + | 354 | WP_061051360.1 | hypothetical protein | - |
| AL543_RS21510 | 1178574..1178762 | - | 189 | Protein_1121 | DUF645 family protein | - |
| AL543_RS05845 | 1179048..1179491 | - | 444 | WP_061051361.1 | hypothetical protein | - |
| AL543_RS05850 | 1179774..1179992 | - | 219 | WP_061051362.1 | DUF3709 domain-containing protein | - |
| AL543_RS05855 | 1180409..1180642 | - | 234 | WP_081096058.1 | DUF3709 domain-containing protein | - |
| AL543_RS05860 | 1180663..1180854 | - | 192 | Protein_1125 | DUF3709 domain-containing protein | - |
| AL543_RS05865 | 1180915..1181460 | - | 546 | WP_061051363.1 | hypothetical protein | - |
| AL543_RS05870 | 1181741..1182001 | - | 261 | WP_151898470.1 | DUF3709 domain-containing protein | - |
| AL543_RS05875 | 1182246..1182629 | - | 384 | WP_061051356.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1086679..1234651 | 147972 | |
| - | inside | Integron | - | - | 1108123..1230683 | 122560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11669.37 Da Isoelectric Point: 9.9572
>T60012 WP_017420621.1 NZ_CP014042:1177392-1177691 [Vibrio mimicus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA
Download Length: 300 bp
>T60012 NZ_CP014042:1177392-1177691 [Vibrio mimicus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGATATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATCCTTCACAAAAGCATGGATGTGAATCCAATTTTGGGCGCATAA
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGATATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATCCTTCACAAAAGCATGGATGTGAATCCAATTTTGGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8953.88 Da Isoelectric Point: 4.2213
>AT60012 WP_011080384.1 NZ_CP014042:1177153-1177395 [Vibrio mimicus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK
Download Length: 243 bp
>AT60012 NZ_CP014042:1177153-1177395 [Vibrio mimicus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|