Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 1169167..1169738 Replicon chromosome
Accession NZ_CP014042
Organism Vibrio mimicus strain FDAARGOS_112

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag AL543_RS05715 Protein ID WP_000351248.1
Coordinates 1169167..1169568 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag AL543_RS05720 Protein ID WP_001080654.1
Coordinates 1169568..1169738 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL543_RS05670 1164558..1165223 - 666 WP_061051354.1 site-specific DNA-methyltransferase -
AL543_RS05680 1165719..1166192 - 474 WP_061051314.1 GrpB family protein -
AL543_RS05690 1166326..1166880 - 555 WP_081096078.1 hypothetical protein -
AL543_RS05695 1166992..1167735 - 744 WP_088900005.1 hypothetical protein -
AL543_RS05700 1168001..1168261 - 261 WP_151898470.1 DUF3709 domain-containing protein -
AL543_RS05705 1168523..1168945 - 423 WP_045612975.1 VOC family protein -
AL543_RS05710 1169054..1169197 - 144 WP_167389953.1 DUF3265 domain-containing protein -
AL543_RS05715 1169167..1169568 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AL543_RS05720 1169568..1169738 - 171 WP_001080654.1 hypothetical protein Antitoxin
AL543_RS05725 1169918..1170301 - 384 WP_061051356.1 hypothetical protein -
AL543_RS05730 1170452..1170838 - 387 WP_061051357.1 VOC family protein -
AL543_RS05735 1170828..1170929 - 102 WP_081096080.1 acetyltransferase -
AL543_RS05740 1171014..1171562 - 549 WP_061051358.1 hypothetical protein -
AL543_RS05745 1171582..1171704 - 123 Protein_1105 DUF3265 domain-containing protein -
AL543_RS05750 1171701..1172060 - 360 WP_029856942.1 VOC family protein -
AL543_RS05755 1172345..1172605 - 261 WP_151898470.1 DUF3709 domain-containing protein -
AL543_RS05760 1172875..1173426 - 552 WP_061051359.1 sugar O-acetyltransferase -
AL543_RS05765 1173590..1174429 - 840 WP_055032240.1 hypothetical protein -
AL543_RS21885 1174457..1174567 - 111 WP_082798255.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086679..1234651 147972
- inside Integron - - 1108123..1230683 122560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T60010 WP_000351248.1 NZ_CP014042:c1169568-1169167 [Vibrio mimicus]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T60010 NZ_CP014042:c1169568-1169167 [Vibrio mimicus]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAACTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT60010 WP_001080654.1 NZ_CP014042:c1169738-1169568 [Vibrio mimicus]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT60010 NZ_CP014042:c1169738-1169568 [Vibrio mimicus]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References