Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1130698..1131226 | Replicon | chromosome |
| Accession | NZ_CP014042 | ||
| Organism | Vibrio mimicus strain FDAARGOS_112 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | AL543_RS05285 | Protein ID | WP_000221352.1 |
| Coordinates | 1130936..1131226 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | AL543_RS05280 | Protein ID | WP_061051339.1 |
| Coordinates | 1130698..1130946 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL543_RS21445 | 1125800..1125952 | - | 153 | Protein_1014 | DUF3709 domain-containing protein | - |
| AL543_RS05230 | 1125942..1126064 | - | 123 | WP_104408363.1 | DUF3265 domain-containing protein | - |
| AL543_RS21450 | 1126049..1126375 | - | 327 | WP_167389937.1 | hypothetical protein | - |
| AL543_RS05240 | 1127175..1127420 | - | 246 | WP_123772160.1 | hypothetical protein | - |
| AL543_RS05245 | 1127540..1128748 | - | 1209 | WP_061051325.1 | IS4 family transposase | - |
| AL543_RS21455 | 1129090..1129146 | - | 57 | WP_114733427.1 | DUF645 family protein | - |
| AL543_RS05255 | 1129147..1129273 | - | 127 | Protein_1021 | DUF645 family protein | - |
| AL543_RS21460 | 1129626..1129664 | - | 39 | WP_108244118.1 | hypothetical protein | - |
| AL543_RS05270 | 1129680..1129807 | - | 128 | Protein_1023 | DUF645 family protein | - |
| AL543_RS05275 | 1130162..1130333 | - | 172 | Protein_1024 | DUF645 family protein | - |
| AL543_RS05280 | 1130698..1130946 | + | 249 | WP_061051339.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL543_RS05285 | 1130936..1131226 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL543_RS05290 | 1131354..1131746 | - | 393 | WP_041202691.1 | nuclear transport factor 2 family protein | - |
| AL543_RS05300 | 1131892..1132509 | - | 618 | WP_061051340.1 | plasmid pRiA4b ORF-3 family protein | - |
| AL543_RS05305 | 1132793..1133029 | - | 237 | WP_081096061.1 | DUF3709 domain-containing protein | - |
| AL543_RS05310 | 1133430..1133663 | - | 234 | WP_081096058.1 | DUF3709 domain-containing protein | - |
| AL543_RS21465 | 1133684..1133851 | - | 168 | Protein_1031 | DUF3709 domain-containing protein | - |
| AL543_RS05320 | 1134501..1134896 | - | 396 | WP_061051341.1 | DUF3465 domain-containing protein | - |
| AL543_RS05325 | 1135061..1135402 | - | 342 | WP_081096063.1 | aldehyde-activating protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1086679..1234651 | 147972 | |
| - | inside | Integron | - | - | 1108123..1230683 | 122560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T60008 WP_000221352.1 NZ_CP014042:1130936-1131226 [Vibrio mimicus]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T60008 NZ_CP014042:1130936-1131226 [Vibrio mimicus]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTTTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTTTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8907.25 Da Isoelectric Point: 4.1079
>AT60008 WP_061051339.1 NZ_CP014042:1130698-1130946 [Vibrio mimicus]
MTARILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTARILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT60008 NZ_CP014042:1130698-1130946 [Vibrio mimicus]
ATGACCGCCAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA
ATGACCGCCAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|