Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1103814..1104373 | Replicon | chromosome |
| Accession | NZ_CP014042 | ||
| Organism | Vibrio mimicus strain FDAARGOS_112 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | AL543_RS05020 | Protein ID | WP_000578471.1 |
| Coordinates | 1104095..1104373 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | AL543_RS05015 | Protein ID | WP_000381183.1 |
| Coordinates | 1103814..1104098 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL543_RS04970 | 1098830..1099231 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| AL543_RS04975 | 1099231..1099401 | - | 171 | WP_001080654.1 | hypothetical protein | - |
| AL543_RS04980 | 1099472..1099564 | - | 93 | WP_208620263.1 | DUF3265 domain-containing protein | - |
| AL543_RS04985 | 1099588..1100604 | - | 1017 | WP_061051319.1 | hypothetical protein | - |
| AL543_RS04990 | 1100884..1101144 | - | 261 | WP_151898470.1 | DUF3709 domain-containing protein | - |
| AL543_RS04995 | 1101389..1101604 | - | 216 | WP_208620264.1 | hypothetical protein | - |
| AL543_RS05000 | 1101751..1102782 | + | 1032 | WP_061051479.1 | IS630 family transposase | - |
| AL543_RS05005 | 1102752..1103093 | - | 342 | WP_208620265.1 | hypothetical protein | - |
| AL543_RS05010 | 1103231..1103611 | - | 381 | WP_061051320.1 | glyoxalase | - |
| AL543_RS05015 | 1103814..1104098 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| AL543_RS05020 | 1104095..1104373 | + | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| AL543_RS05025 | 1104512..1104916 | - | 405 | WP_061051321.1 | hypothetical protein | - |
| AL543_RS05035 | 1105230..1105487 | - | 258 | WP_061051322.1 | hypothetical protein | - |
| AL543_RS05045 | 1105768..1106976 | + | 1209 | WP_061051323.1 | IS4 family transposase | - |
| AL543_RS05050 | 1107099..1107767 | - | 669 | WP_061051324.1 | ATP-dependent Clp protease proteolytic subunit | - |
| AL543_RS05060 | 1108123..1109331 | + | 1209 | WP_061051325.1 | IS4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1086679..1234651 | 147972 | |
| - | inside | IScluster/Tn | - | - | 1101751..1109331 | 7580 | |
| - | inside | Integron | - | - | 1086581..1105487 | 18906 | |
| - | inside | Integron | - | - | 1108123..1230683 | 122560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T60007 WP_000578471.1 NZ_CP014042:1104095-1104373 [Vibrio mimicus]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T60007 NZ_CP014042:1104095-1104373 [Vibrio mimicus]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGATTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT60007 WP_000381183.1 NZ_CP014042:1103814-1104098 [Vibrio mimicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT60007 NZ_CP014042:1103814-1104098 [Vibrio mimicus]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTGGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTGGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |