Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 1098830..1099401 Replicon chromosome
Accession NZ_CP014042
Organism Vibrio mimicus strain FDAARGOS_112

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag AL543_RS04970 Protein ID WP_000351248.1
Coordinates 1098830..1099231 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag AL543_RS04975 Protein ID WP_001080654.1
Coordinates 1099231..1099401 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL543_RS04920 1093831..1094064 - 234 Protein_960 DUF3709 domain-containing protein -
AL543_RS04925 1094085..1094279 - 195 Protein_961 DUF3709 domain-containing protein -
AL543_RS04930 1094336..1095418 - 1083 WP_061051313.1 calcium/sodium antiporter -
AL543_RS04935 1095575..1096048 - 474 WP_061051314.1 GrpB family protein -
AL543_RS21655 1096055..1096135 - 81 WP_167389952.1 hypothetical protein -
AL543_RS04940 1096195..1096941 - 747 WP_061051315.1 hypothetical protein -
AL543_RS04945 1097194..1097430 + 237 WP_061051316.1 RNA recognition motif containing protein -
AL543_RS04955 1097665..1097844 - 180 WP_061051317.1 DUF645 family protein -
AL543_RS04960 1098141..1098677 - 537 WP_061051318.1 GNAT family N-acetyltransferase -
AL543_RS04965 1098717..1098860 - 144 WP_167389953.1 DUF3265 domain-containing protein -
AL543_RS04970 1098830..1099231 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AL543_RS04975 1099231..1099401 - 171 WP_001080654.1 hypothetical protein Antitoxin
AL543_RS04980 1099472..1099564 - 93 WP_208620263.1 DUF3265 domain-containing protein -
AL543_RS04985 1099588..1100604 - 1017 WP_061051319.1 hypothetical protein -
AL543_RS04990 1100884..1101144 - 261 WP_151898470.1 DUF3709 domain-containing protein -
AL543_RS04995 1101389..1101604 - 216 WP_208620264.1 hypothetical protein -
AL543_RS05000 1101751..1102782 + 1032 WP_061051479.1 IS630 family transposase -
AL543_RS05005 1102752..1103093 - 342 WP_208620265.1 hypothetical protein -
AL543_RS05010 1103231..1103611 - 381 WP_061051320.1 glyoxalase -
AL543_RS05015 1103814..1104098 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
AL543_RS05020 1104095..1104373 + 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086679..1234651 147972
- inside IScluster/Tn - - 1101751..1109331 7580
- inside Integron - - 1086581..1105487 18906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T60006 WP_000351248.1 NZ_CP014042:c1099231-1098830 [Vibrio mimicus]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T60006 NZ_CP014042:c1099231-1098830 [Vibrio mimicus]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAACTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT60006 WP_001080654.1 NZ_CP014042:c1099401-1099231 [Vibrio mimicus]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT60006 NZ_CP014042:c1099401-1099231 [Vibrio mimicus]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References