Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1088127..1088625 Replicon chromosome
Accession NZ_CP014042
Organism Vibrio mimicus strain FDAARGOS_112

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag AL543_RS04855 Protein ID WP_000589156.1
Coordinates 1088359..1088625 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag AL543_RS04850 Protein ID WP_000643598.1
Coordinates 1088127..1088372 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL543_RS04820 1084649..1085680 + 1032 WP_167389944.1 IS630 family transposase -
AL543_RS04825 1085713..1085985 - 273 Protein_945 transposase -
AL543_RS04830 1086227..1086406 - 180 Protein_946 DUF645 family protein -
AL543_RS04835 1086679..1087392 - 714 WP_188318523.1 Fic family protein -
AL543_RS04840 1087665..1087826 - 162 WP_061051308.1 DUF645 family protein -
AL543_RS04850 1088127..1088372 - 246 WP_000643598.1 hypothetical protein Antitoxin
AL543_RS04855 1088359..1088625 - 267 WP_000589156.1 BrnT family toxin Toxin
AL543_RS04860 1088862..1089014 - 153 WP_167389951.1 DUF645 family protein -
AL543_RS04875 1089669..1089881 + 213 WP_000526880.1 hypothetical protein -
AL543_RS04880 1089853..1090605 + 753 WP_081096051.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
AL543_RS04885 1090756..1091166 - 411 WP_061051310.1 DUF4279 domain-containing protein -
AL543_RS04890 1091196..1091288 - 93 WP_074050554.1 DUF3265 domain-containing protein -
AL543_RS04895 1091312..1092310 - 999 WP_007468098.1 hypothetical protein -
AL543_RS04900 1092348..1092494 - 147 WP_081096114.1 DUF3265 domain-containing protein -
AL543_RS04905 1092476..1092937 - 462 WP_061051311.1 GNAT family N-acetyltransferase -
AL543_RS04910 1093103..1093516 - 414 WP_061051312.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1086679..1234651 147972
- inside Integron - - 1086581..1105487 18906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T60005 WP_000589156.1 NZ_CP014042:c1088625-1088359 [Vibrio mimicus]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T60005 NZ_CP014042:c1088625-1088359 [Vibrio mimicus]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
GTTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT60005 WP_000643598.1 NZ_CP014042:c1088372-1088127 [Vibrio mimicus]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT60005 NZ_CP014042:c1088372-1088127 [Vibrio mimicus]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References