Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1784088..1784616 | Replicon | chromosome |
| Accession | NZ_CP014040 | ||
| Organism | Vibrio alginolyticus strain FDAARGOS_110 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | AL541_RS08840 | Protein ID | WP_104979416.1 |
| Coordinates | 1784326..1784616 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | AL541_RS08835 | Protein ID | WP_005377003.1 |
| Coordinates | 1784088..1784336 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL541_RS08765 | 1779406..1779837 | - | 432 | WP_085570156.1 | hypothetical protein | - |
| AL541_RS08770 | 1779911..1780003 | - | 93 | WP_079764222.1 | DUF3265 domain-containing protein | - |
| AL541_RS08775 | 1780018..1780428 | - | 411 | WP_021033956.1 | cytidine deaminase | - |
| AL541_RS08780 | 1780577..1781425 | - | 849 | WP_104979410.1 | hypothetical protein | - |
| AL541_RS08785 | 1781464..1781586 | - | 123 | WP_079753428.1 | DUF3265 domain-containing protein | - |
| AL541_RS08800 | 1781975..1782259 | - | 285 | WP_017449629.1 | nucleotide pyrophosphohydrolase | - |
| AL541_RS08805 | 1782304..1782393 | - | 90 | WP_192947945.1 | DUF3265 domain-containing protein | - |
| AL541_RS08810 | 1782428..1782838 | - | 411 | WP_031847708.1 | hydrolase | - |
| AL541_RS08815 | 1782827..1782929 | - | 103 | Protein_1644 | nitrate reductase | - |
| AL541_RS08820 | 1783024..1783257 | - | 234 | WP_053397245.1 | hypothetical protein | - |
| AL541_RS08825 | 1783395..1783892 | - | 498 | WP_104979413.1 | hypothetical protein | - |
| AL541_RS08835 | 1784088..1784336 | + | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL541_RS08840 | 1784326..1784616 | + | 291 | WP_104979416.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL541_RS08850 | 1785174..1785296 | - | 123 | WP_080767753.1 | DUF3265 domain-containing protein | - |
| AL541_RS08855 | 1785293..1785592 | - | 300 | WP_104979418.1 | hypothetical protein | - |
| AL541_RS08860 | 1785652..1785723 | - | 72 | WP_104980035.1 | DUF3265 domain-containing protein | - |
| AL541_RS08865 | 1785728..1786012 | - | 285 | WP_104979420.1 | antibiotic biosynthesis monooxygenase | - |
| AL541_RS08870 | 1786041..1786133 | - | 93 | WP_017821997.1 | DUF3265 domain-containing protein | - |
| AL541_RS08875 | 1786190..1786636 | - | 447 | WP_192947854.1 | DUF2314 domain-containing protein | - |
| AL541_RS08880 | 1786928..1788274 | + | 1347 | WP_104979423.1 | integrase arm-type DNA-binding domain-containing protein | - |
| AL541_RS08885 | 1788415..1789257 | + | 843 | WP_104979425.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1677181..1802662 | 125481 | |
| - | inside | Integron | - | - | 1727228..1786636 | 59408 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11260.27 Da Isoelectric Point: 10.6832
>T60004 WP_104979416.1 NZ_CP014040:1784326-1784616 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGANNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGANNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T60004 NZ_CP014040:1784326-1784616 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTAACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCCGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTAACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCCGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT60004 WP_005377003.1 NZ_CP014040:1784088-1784336 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT60004 NZ_CP014040:1784088-1784336 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGAGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTATTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGAGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTATTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|