Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1717852..1718411 | Replicon | chromosome |
| Accession | NZ_CP014040 | ||
| Organism | Vibrio alginolyticus strain FDAARGOS_110 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | AL541_RS08140 | Protein ID | WP_104979315.1 |
| Coordinates | 1718133..1718411 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | AL541_RS08135 | Protein ID | WP_005398409.1 |
| Coordinates | 1717852..1718136 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL541_RS08095 | 1713370..1713459 | - | 90 | WP_077345960.1 | DUF3265 domain-containing protein | - |
| AL541_RS08100 | 1714043..1714423 | - | 381 | WP_104979310.1 | STAS/SEC14 domain-containing protein | - |
| AL541_RS08105 | 1714647..1714937 | - | 291 | WP_042523463.1 | hypothetical protein | - |
| AL541_RS08110 | 1715084..1715482 | - | 399 | WP_042524338.1 | SMI1/KNR4 family protein | - |
| AL541_RS08115 | 1715599..1716558 | - | 960 | WP_104975411.1 | phosphotransferase | - |
| AL541_RS08120 | 1716732..1717118 | - | 387 | WP_104979311.1 | hypothetical protein | - |
| AL541_RS08125 | 1717115..1717531 | - | 417 | WP_104979313.1 | hypothetical protein | - |
| AL541_RS08130 | 1717683..1717775 | - | 93 | WP_104975412.1 | DUF3265 domain-containing protein | - |
| AL541_RS08135 | 1717852..1718136 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| AL541_RS08140 | 1718133..1718411 | + | 279 | WP_104979315.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL541_RS08145 | 1718548..1719084 | - | 537 | WP_104975413.1 | nucleotidyltransferase family protein | - |
| AL541_RS08150 | 1719229..1719777 | - | 549 | WP_104979317.1 | hypothetical protein | - |
| AL541_RS08155 | 1719927..1720238 | - | 312 | WP_136977026.1 | hypothetical protein | - |
| AL541_RS08160 | 1720380..1720889 | - | 510 | WP_104979320.1 | DUF4145 domain-containing protein | - |
| AL541_RS08165 | 1720916..1721059 | - | 144 | WP_192947933.1 | DUF3265 domain-containing protein | - |
| AL541_RS08170 | 1721466..1721558 | - | 93 | WP_115386054.1 | DUF3265 domain-containing protein | - |
| AL541_RS08175 | 1721573..1722571 | - | 999 | WP_104979324.1 | alpha/beta fold hydrolase | - |
| AL541_RS08180 | 1723081..1723171 | - | 91 | Protein_1529 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1677181..1802662 | 125481 | |
| - | inside | Integron | - | - | 1687369..1724062 | 36693 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10918.64 Da Isoelectric Point: 4.4558
>T60003 WP_104979315.1 NZ_CP014040:1718133-1718411 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPKD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPKD
Download Length: 279 bp
>T60003 NZ_CP014040:1718133-1718411 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTTATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAAAAACAAAAATTTCCTAAAGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTTATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAAAAACAAAAATTTCCTAAAGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT60003 WP_005398409.1 NZ_CP014040:1717852-1718136 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT60003 NZ_CP014040:1717852-1718136 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|