Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 530584..531112 | Replicon | chromosome |
| Accession | NZ_CP014038 | ||
| Organism | Vibrio harveyi strain FDAARGOS_107 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2N7HV18 |
| Locus tag | AL538_RS02665 | Protein ID | WP_047010341.1 |
| Coordinates | 530822..531112 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A454B3E5 |
| Locus tag | AL538_RS02660 | Protein ID | WP_050940254.1 |
| Coordinates | 530584..530832 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL538_RS02600 (AL538_27570) | 525678..525770 | - | 93 | WP_196333301.1 | DUF3265 domain-containing protein | - |
| AL538_RS02605 (AL538_02450) | 525796..526257 | - | 462 | WP_017190375.1 | hypothetical protein | - |
| AL538_RS02615 (AL538_02455) | 527001..527231 | - | 231 | WP_005446124.1 | hypothetical protein | - |
| AL538_RS02620 (AL538_02460) | 527233..527586 | - | 354 | WP_031858641.1 | hypothetical protein | - |
| AL538_RS02625 (AL538_27580) | 527744..527836 | - | 93 | WP_140131350.1 | DUF3265 domain-containing protein | - |
| AL538_RS02635 (AL538_02470) | 528541..529122 | - | 582 | WP_123947171.1 | hypothetical protein | - |
| AL538_RS02640 (AL538_27585) | 529211..529303 | - | 93 | WP_077261317.1 | DUF3265 domain-containing protein | - |
| AL538_RS02645 (AL538_02475) | 529330..529830 | - | 501 | WP_061065140.1 | hypothetical protein | - |
| AL538_RS02650 (AL538_27590) | 529858..529950 | - | 93 | WP_208631280.1 | DUF3265 domain-containing protein | - |
| AL538_RS02655 (AL538_02480) | 529965..530375 | - | 411 | WP_025613414.1 | cytidine deaminase | - |
| AL538_RS28935 | 530441..530509 | - | 69 | WP_074531725.1 | DUF3265 domain-containing protein | - |
| AL538_RS02660 (AL538_02485) | 530584..530832 | + | 249 | WP_050940254.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL538_RS02665 (AL538_02490) | 530822..531112 | + | 291 | WP_047010341.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL538_RS28940 | 531679..531771 | - | 93 | WP_208631286.1 | DUF3265 domain-containing protein | - |
| AL538_RS02680 (AL538_02495) | 531792..532319 | - | 528 | WP_005445729.1 | CbrC family protein | - |
| AL538_RS02685 (AL538_27605) | 532348..532479 | - | 132 | WP_017420680.1 | DUF3265 domain-containing protein | - |
| AL538_RS02695 (AL538_27615) | 532968..533057 | - | 90 | WP_078231685.1 | DUF3265 domain-containing protein | - |
| AL538_RS28765 | 533186..533467 | + | 282 | WP_050914603.1 | hypothetical protein | - |
| AL538_RS02700 (AL538_27620) | 533588..533677 | - | 90 | WP_079766072.1 | DUF3265 domain-containing protein | - |
| AL538_RS02705 (AL538_02505) | 533695..534312 | - | 618 | WP_061065141.1 | hypothetical protein | - |
| AL538_RS02710 (AL538_02510) | 534426..535103 | - | 678 | WP_050933034.1 | HNH endonuclease | - |
| AL538_RS02715 (AL538_27625) | 535137..535268 | - | 132 | WP_017821410.1 | DUF3265 domain-containing protein | - |
| AL538_RS02725 (AL538_27630) | 535746..535901 | - | 156 | WP_104411068.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 497112..600367 | 103255 | |
| - | inside | Integron | - | - | 502921..600367 | 97446 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11275.28 Da Isoelectric Point: 10.5932
>T60001 WP_047010341.1 NZ_CP014038:530822-531112 [Vibrio harveyi]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDIIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDIIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T60001 NZ_CP014038:530822-531112 [Vibrio harveyi]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATATCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATATCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9052.34 Da Isoelectric Point: 3.9610
>AT60001 WP_050940254.1 NZ_CP014038:530584-530832 [Vibrio harveyi]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVSID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVSID
DL
Download Length: 249 bp
>AT60001 NZ_CP014038:530584-530832 [Vibrio harveyi]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCCTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAGTATTGAT
GACCTATAA
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCCTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAGTATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N7HV18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A454B3E5 |