Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 502631..503178 | Replicon | chromosome |
| Accession | NZ_CP014038 | ||
| Organism | Vibrio harveyi strain FDAARGOS_107 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A454B353 |
| Locus tag | AL538_RS02325 | Protein ID | WP_005445657.1 |
| Coordinates | 502631..502933 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A454B3H2 |
| Locus tag | AL538_RS02330 | Protein ID | WP_005445660.1 |
| Coordinates | 502921..503178 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL538_RS28655 | 498207..498452 | - | 246 | WP_123947168.1 | hypothetical protein | - |
| AL538_RS02275 (AL538_02240) | 498764..499054 | - | 291 | WP_017190343.1 | hypothetical protein | - |
| AL538_RS02280 (AL538_02245) | 499117..499368 | - | 252 | WP_005445646.1 | DUF2442 domain-containing protein | - |
| AL538_RS02295 (AL538_02255) | 500615..501046 | - | 432 | WP_005445651.1 | GNAT family N-acetyltransferase | - |
| AL538_RS02300 (AL538_02260) | 501255..501671 | - | 417 | WP_005445653.1 | hypothetical protein | - |
| AL538_RS02305 (AL538_27455) | 501687..501857 | - | 171 | WP_080573696.1 | DUF3265 domain-containing protein | - |
| AL538_RS02310 (AL538_02265) | 501912..502106 | - | 195 | WP_061065127.1 | hypothetical protein | - |
| AL538_RS02315 (AL538_02270) | 502115..502342 | - | 228 | WP_017190347.1 | type II toxin-antitoxin system YafO family toxin | - |
| AL538_RS02320 (AL538_27460) | 502435..502587 | + | 153 | Protein_457 | IS30 family transposase | - |
| AL538_RS02325 (AL538_02275) | 502631..502933 | - | 303 | WP_005445657.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL538_RS02330 (AL538_02280) | 502921..503178 | - | 258 | WP_005445660.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL538_RS02335 (AL538_27465) | 503260..503361 | - | 102 | WP_100216259.1 | DUF3265 domain-containing protein | - |
| AL538_RS02340 (AL538_02285) | 503372..503806 | - | 435 | WP_005445664.1 | hypothetical protein | - |
| AL538_RS02345 (AL538_02290) | 503785..504219 | - | 435 | WP_047517096.1 | hypothetical protein | - |
| AL538_RS28755 | 504488..504643 | - | 156 | WP_017190350.1 | hypothetical protein | - |
| AL538_RS02350 (AL538_02295) | 504640..504819 | - | 180 | WP_017190351.1 | hypothetical protein | - |
| AL538_RS02355 (AL538_02300) | 504843..505088 | - | 246 | WP_080573697.1 | BrnT family toxin | - |
| AL538_RS02360 (AL538_02305) | 505376..505843 | - | 468 | WP_123947169.1 | hypothetical protein | - |
| AL538_RS02365 (AL538_02310) | 505849..506322 | - | 474 | WP_208631279.1 | hypothetical protein | - |
| AL538_RS02370 (AL538_27470) | 506593..506730 | - | 138 | WP_081053578.1 | DUF3265 domain-containing protein | - |
| AL538_RS02385 (AL538_02320) | 507264..507632 | - | 369 | WP_033007242.1 | DUF2195 family protein | - |
| AL538_RS02390 (AL538_02325) | 507622..508141 | - | 520 | Protein_470 | DUF2778 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 497112..600367 | 103255 | |
| - | inside | Integron | - | - | 502921..600367 | 97446 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11681.63 Da Isoelectric Point: 6.9800
>T60000 WP_005445657.1 NZ_CP014038:c502933-502631 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPDLKHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLNKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPDLKHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLNKQ
Download Length: 303 bp
>T60000 NZ_CP014038:c502933-502631 [Vibrio harveyi]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGTTTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGATCTAAAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTTTGTTTGTTATGCGCGCAGAGAGAGATTTGCGTAAGTTCTTGTTAAATAAGCAATAA
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGTTTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGATCTAAAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTTTGTTTGTTATGCGCGCAGAGAGAGATTTGCGTAAGTTCTTGTTAAATAAGCAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9548.06 Da Isoelectric Point: 7.3177
>AT60000 WP_005445660.1 NZ_CP014038:c503178-502921 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKGKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKGKM
SKWLK
Download Length: 258 bp
>AT60000 NZ_CP014038:c503178-502921 [Vibrio harveyi]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATTCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGGCAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATTCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGGCAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A454B353 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A454B3H2 |