Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2872206..2872765 | Replicon | chromosome |
| Accession | NZ_CP014036 | ||
| Organism | Vibrio diabolicus strain FDAARGOS_105 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | AL537_RS13935 | Protein ID | WP_104971836.1 |
| Coordinates | 2872487..2872765 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | AL537_RS13930 | Protein ID | WP_005398409.1 |
| Coordinates | 2872206..2872490 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL537_RS13865 | 2867365..2867502 | - | 138 | WP_104971832.1 | DUF3265 domain-containing protein | - |
| AL537_RS13870 | 2867913..2868035 | - | 123 | WP_081947328.1 | DUF3265 domain-containing protein | - |
| AL537_RS13875 | 2868020..2868496 | - | 477 | WP_042773224.1 | GNAT family N-acetyltransferase | - |
| AL537_RS13880 | 2868530..2868622 | - | 93 | WP_079757351.1 | DUF3265 domain-containing protein | - |
| AL537_RS13885 | 2868637..2869071 | - | 435 | WP_104971833.1 | GNAT family N-acetyltransferase | - |
| AL537_RS13890 | 2869195..2869629 | - | 435 | Protein_2526 | GNAT family N-acetyltransferase | - |
| AL537_RS13900 | 2869792..2870076 | - | 285 | WP_104971834.1 | nucleotide pyrophosphohydrolase | - |
| AL537_RS13905 | 2870199..2870645 | - | 447 | WP_104971835.1 | GNAT family N-acetyltransferase | - |
| AL537_RS13910 | 2870782..2871573 | - | 792 | WP_086582449.1 | DUF3800 domain-containing protein | - |
| AL537_RS26100 | 2871618..2871707 | - | 90 | WP_074534792.1 | DUF3265 domain-containing protein | - |
| AL537_RS13920 | 2871739..2872011 | - | 273 | WP_005462157.1 | nicotinamide mononucleotide transporter | - |
| AL537_RS13925 | 2872038..2872129 | - | 92 | Protein_2532 | DUF3265 domain-containing protein | - |
| AL537_RS13930 | 2872206..2872490 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| AL537_RS13935 | 2872487..2872765 | + | 279 | WP_104971836.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL537_RS13940 | 2872903..2873418 | - | 516 | WP_065765291.1 | hypothetical protein | - |
| AL537_RS13945 | 2873446..2873559 | - | 114 | WP_013571684.1 | DUF3265 domain-containing protein | - |
| AL537_RS13950 | 2873995..2874084 | - | 90 | WP_078511465.1 | DUF3265 domain-containing protein | - |
| AL537_RS13955 | 2874115..2874468 | - | 354 | WP_000384364.1 | hypothetical protein | - |
| AL537_RS13960 | 2874520..2874612 | - | 93 | WP_075984057.1 | DUF3265 domain-containing protein | - |
| AL537_RS13965 | 2874627..2875019 | - | 393 | WP_065646851.1 | SMI1/KNR4 family protein | - |
| AL537_RS13970 | 2875148..2875510 | - | 363 | WP_104971839.1 | hypothetical protein | - |
| AL537_RS13980 | 2876512..2877054 | - | 543 | WP_104971841.1 | hypothetical protein | - |
| AL537_RS26015 | 2877209..2877466 | - | 258 | WP_167394165.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2866736..2903708 | 36972 | |
| - | inside | Integron | - | - | 2865956..2902590 | 36634 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10892.56 Da Isoelectric Point: 4.2698
>T59999 WP_104971836.1 NZ_CP014036:2872487-2872765 [Vibrio diabolicus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDDLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDDLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T59999 NZ_CP014036:2872487-2872765 [Vibrio diabolicus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACGACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACGACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT59999 WP_005398409.1 NZ_CP014036:2872206-2872490 [Vibrio diabolicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT59999 NZ_CP014036:2872206-2872490 [Vibrio diabolicus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|