Detailed information of TA system TA059998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2866736..2867283
• Replicon: chromosome
• Accession: NZ_CP014036
• Organism: Vibrio diabolicus strain FDAARGOS_105

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL537_RS13855
• Protein ID: WP_104971831.1
• Coordinates: 2866736..2867038 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y0N039
• Locus tag: AL537_RS13860
• Protein ID: WP_042524229.1
• Coordinates: 2867026..2867283 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL537_RS13820	2861849..2862571	+	723	WP_208623546.1	helix-turn-helix domain-containing protein	-
AL537_RS13830	2863019..2864872	-	1854	WP_025607840.1	ATP-binding protein	-
AL537_RS13840	2865969..2866058	-	90	WP_104972082.1	DUF3265 domain-containing protein	-
AL537_RS13850	2866609..2866698	-	90	WP_079880725.1	DUF3265 domain-containing protein	-
AL537_RS13855	2866736..2867038	-	303	WP_104971831.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL537_RS13860	2867026..2867283	-	258	WP_042524229.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AL537_RS13865	2867365..2867502	-	138	WP_104971832.1	DUF3265 domain-containing protein	-
AL537_RS13870	2867913..2868035	-	123	WP_081947328.1	DUF3265 domain-containing protein	-
AL537_RS13875	2868020..2868496	-	477	WP_042773224.1	GNAT family N-acetyltransferase	-
AL537_RS13880	2868530..2868622	-	93	WP_079757351.1	DUF3265 domain-containing protein	-
AL537_RS13885	2868637..2869071	-	435	WP_104971833.1	GNAT family N-acetyltransferase	-
AL537_RS13890	2869195..2869629	-	435	Protein_2526	GNAT family N-acetyltransferase	-
AL537_RS13900	2869792..2870076	-	285	WP_104971834.1	nucleotide pyrophosphohydrolase	-
AL537_RS13905	2870199..2870645	-	447	WP_104971835.1	GNAT family N-acetyltransferase	-
AL537_RS13910	2870782..2871573	-	792	WP_086582449.1	DUF3800 domain-containing protein	-
AL537_RS26100	2871618..2871707	-	90	WP_074534792.1	DUF3265 domain-containing protein	-
AL537_RS13920	2871739..2872011	-	273	WP_005462157.1	nicotinamide mononucleotide transporter	-
AL537_RS13925	2872038..2872129	-	92	Protein_2532	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2866736..2903708	36972
	-	inside	Integron	-	-	2865956..2902590	36634

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11696.59 Da
• Isoelectric Point: 5.1765

>T59998 WP_104971831.1 NZ_CP014036:c2867038-2866736 [Vibrio diabolicus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLNYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T59998 NZ_CP014036:c2867038-2866736 [Vibrio diabolicus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCAGAATACATAGCACTTGAAAATATTGT
TGCTGCAAAGCAGTTAGTACAAACGATCTTCTCAAAAGTCGAACGACTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAACTAGAACATTTAAATTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAGCAAGATGGCGACAAGGTG
TTTATTCTTTTTGTAATGCGTGCTGAGAGAGATTTACGGAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9592.07 Da
• Isoelectric Point: 6.7273

>AT59998 WP_042524229.1 NZ_CP014036:c2867283-2867026 [Vibrio diabolicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAVSHDEAKEKM
SKWLK

Nucleotide

• Length: 258 bp

>AT59998 NZ_CP014036:c2867283-2867026 [Vibrio diabolicus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGCCAAGCAACCAAGATCCTCGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGATTACGAGTTCATGCAAAATCGTTTGGCTA
TTCTTGAGGGGATCGCACGAGGTGAACGTGCACTAGCTGACGGTAAAGCGGTAAGTCATGATGAAGCCAAGGAAAAAATG
TCAAAATGGCTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y0N039