Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 2866736..2867283 | Replicon | chromosome |
| Accession | NZ_CP014036 | ||
| Organism | Vibrio diabolicus strain FDAARGOS_105 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | AL537_RS13855 | Protein ID | WP_104971831.1 |
| Coordinates | 2866736..2867038 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A7Y0N039 |
| Locus tag | AL537_RS13860 | Protein ID | WP_042524229.1 |
| Coordinates | 2867026..2867283 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL537_RS13820 | 2861849..2862571 | + | 723 | WP_208623546.1 | helix-turn-helix domain-containing protein | - |
| AL537_RS13830 | 2863019..2864872 | - | 1854 | WP_025607840.1 | ATP-binding protein | - |
| AL537_RS13840 | 2865969..2866058 | - | 90 | WP_104972082.1 | DUF3265 domain-containing protein | - |
| AL537_RS13850 | 2866609..2866698 | - | 90 | WP_079880725.1 | DUF3265 domain-containing protein | - |
| AL537_RS13855 | 2866736..2867038 | - | 303 | WP_104971831.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL537_RS13860 | 2867026..2867283 | - | 258 | WP_042524229.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL537_RS13865 | 2867365..2867502 | - | 138 | WP_104971832.1 | DUF3265 domain-containing protein | - |
| AL537_RS13870 | 2867913..2868035 | - | 123 | WP_081947328.1 | DUF3265 domain-containing protein | - |
| AL537_RS13875 | 2868020..2868496 | - | 477 | WP_042773224.1 | GNAT family N-acetyltransferase | - |
| AL537_RS13880 | 2868530..2868622 | - | 93 | WP_079757351.1 | DUF3265 domain-containing protein | - |
| AL537_RS13885 | 2868637..2869071 | - | 435 | WP_104971833.1 | GNAT family N-acetyltransferase | - |
| AL537_RS13890 | 2869195..2869629 | - | 435 | Protein_2526 | GNAT family N-acetyltransferase | - |
| AL537_RS13900 | 2869792..2870076 | - | 285 | WP_104971834.1 | nucleotide pyrophosphohydrolase | - |
| AL537_RS13905 | 2870199..2870645 | - | 447 | WP_104971835.1 | GNAT family N-acetyltransferase | - |
| AL537_RS13910 | 2870782..2871573 | - | 792 | WP_086582449.1 | DUF3800 domain-containing protein | - |
| AL537_RS26100 | 2871618..2871707 | - | 90 | WP_074534792.1 | DUF3265 domain-containing protein | - |
| AL537_RS13920 | 2871739..2872011 | - | 273 | WP_005462157.1 | nicotinamide mononucleotide transporter | - |
| AL537_RS13925 | 2872038..2872129 | - | 92 | Protein_2532 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2866736..2903708 | 36972 | |
| - | inside | Integron | - | - | 2865956..2902590 | 36634 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11696.59 Da Isoelectric Point: 5.1765
>T59998 WP_104971831.1 NZ_CP014036:c2867038-2866736 [Vibrio diabolicus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLNYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLNYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T59998 NZ_CP014036:c2867038-2866736 [Vibrio diabolicus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCAGAATACATAGCACTTGAAAATATTGT
TGCTGCAAAGCAGTTAGTACAAACGATCTTCTCAAAAGTCGAACGACTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAACTAGAACATTTAAATTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAGCAAGATGGCGACAAGGTG
TTTATTCTTTTTGTAATGCGTGCTGAGAGAGATTTACGGAAGTTCTTGTTGAGTAAGCAATAA
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCAGAATACATAGCACTTGAAAATATTGT
TGCTGCAAAGCAGTTAGTACAAACGATCTTCTCAAAAGTCGAACGACTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAACTAGAACATTTAAATTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAGCAAGATGGCGACAAGGTG
TTTATTCTTTTTGTAATGCGTGCTGAGAGAGATTTACGGAAGTTCTTGTTGAGTAAGCAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9592.07 Da Isoelectric Point: 6.7273
>AT59998 WP_042524229.1 NZ_CP014036:c2867283-2867026 [Vibrio diabolicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAVSHDEAKEKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAVSHDEAKEKM
SKWLK
Download Length: 258 bp
>AT59998 NZ_CP014036:c2867283-2867026 [Vibrio diabolicus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGCCAAGCAACCAAGATCCTCGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGATTACGAGTTCATGCAAAATCGTTTGGCTA
TTCTTGAGGGGATCGCACGAGGTGAACGTGCACTAGCTGACGGTAAAGCGGTAAGTCATGATGAAGCCAAGGAAAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTTAAACGCCAAGCAACCAAGATCCTCGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGATTACGAGTTCATGCAAAATCGTTTGGCTA
TTCTTGAGGGGATCGCACGAGGTGAACGTGCACTAGCTGACGGTAAAGCGGTAAGTCATGATGAAGCCAAGGAAAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|