Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2890582..2892257 Replicon chromosome
Accession NZ_CP014035
Organism Vibrio fluvialis strain FDAARGOS_104

Toxin (Protein)


Gene name panT Uniprot ID A0A0X8LPQ1
Locus tag AL536_RS44070 Protein ID WP_001280596.1
Coordinates 2891046..2892257 (+) Length 404 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0X8LPP8
Locus tag AL536_RS44065 Protein ID WP_000649312.1
Coordinates 2890582..2891049 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL536_RS44035 2885989..2886165 - 177 WP_001914530.1 hypothetical protein -
AL536_RS44040 2886169..2886612 - 444 WP_055467186.1 DUF2787 domain-containing protein -
AL536_RS44045 2886664..2887101 - 438 WP_061057115.1 DUF2787 domain-containing protein -
AL536_RS44050 2887098..2887571 - 474 WP_061057116.1 DNA repair protein RadC -
AL536_RS45490 2887788..2887925 + 138 WP_155724448.1 hypothetical protein -
AL536_RS44055 2887991..2889628 + 1638 WP_061057117.1 RNA-directed DNA polymerase -
AL536_RS44060 2889655..2890362 + 708 WP_123946169.1 hypothetical protein -
AL536_RS44065 2890582..2891049 + 468 WP_000649312.1 DUF4065 domain-containing protein Antitoxin
AL536_RS44070 2891046..2892257 + 1212 WP_001280596.1 RelA/SpoT domain-containing protein Toxin
AL536_RS44075 2892503..2893612 - 1110 WP_061057248.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
AL536_RS44080 2894010..2895833 + 1824 WP_061057119.1 TonB-dependent receptor -
AL536_RS44085 2895877..2896551 + 675 WP_061057120.1 ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2867183..2892257 25074


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(86-226)

Antitoxin

Antitoxin SocA-like, Panacea domain

(32-123)


Sequences

Toxin        


Download         Length: 404 a.a.        Molecular weight: 45837.66 Da        Isoelectric Point: 5.2762

>T59996 WP_001280596.1 NZ_CP014035:2891046-2892257 [Vibrio fluvialis]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYSNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Download         Length: 1212 bp

>T59996 NZ_CP014035:2891046-2892257 [Vibrio fluvialis]
GTGAGTGATAAAGAAAAACGTGTCGTCAGTTTTCAAATTGACGACACTCCCACCGCCGAACAGGCATCAAAAAACTTCCA
AGACGACTATGAGCTGTGCTTCCAAGATTTTCTTGAAAGAACGGTTGATGAAAGTGCCGCTGAAGATTTCTCATACTCCA
ATAACGGAGTTAAGAAAGCAGGGCGACGACTACGCAAGAAAGAAGGCGATCTTAAATCCGCGACTGCGACCATCCAGCAG
TTTCGCGCAGCCCATGAAAAACCACTGAATACTATCGCCTACCTTGTTGGTCGATGTTGTCGAGAGCTTGGGATAGATGT
TAAACCAGTGACACGACTGAAGCGTTTAGAAACCATAGTAGATAAGCTACAGCGTAAATCTCTTGATGGTGAAACTACGA
ATGCGACCTGTGTAACCAATATGAACGATATTGGTGGTTGTCGGGCAATTTTCCCTGATCTTGAATCGTTGGAGAAAGCA
AAAGAGCGCCTGCAAGTTACCGTAGAAAAAGTAGGTCGAATTAAGATTAAGGACATTGATGACTACATCACTAATCCTAA
ACCTAATGACTGCGGATACCGAAGTTTGCATGTTATATATCGTTATGACCATGCCAGCGGTAAAAGTTTTAATATAGAAG
CTCAGCTACGTACTCGTCTTCAGCATCTTTGGGCGACAACAGTAGAAATCGTCGATATTTTGGAAGGTACTAAGATTAAG
ACGCATTCCCATAGCCCAGATGAAGACAAAGAGAAGTTGCAGGTTCAGTGGGAAGAGCTACTTTCCATCATGAGTCAGTA
TATTGCTGACGCCGAAGGTGCAATAGAGTTAAGCAATGACAATAGGACTCAGTTTTCAAATAGACTGATTGAATTGAATC
GTGAAATCAATGCATTGAGTCGATTGAGAAGCTTTAAAATCTTATCTGAAAAAGTTGAAGGTTGTCGTGATGGCTCAATA
GAACATGTTCTGTTAGTTATTGACGAAACTTCGTTAGAAATGATTTTTAGTGAAGAGTTTGAGAATTATACCCAAGCTAT
CTCGGTTTACAACGCAGCTGAGAAAATGACTCGTAGTCATGCGAGATTAAACACCCTTCTTATATCTACGAAAAATATGG
GGCAACTATCAGAAGCATACCCCAACTATCTAGGTGACTGTGCTTCATTCATCACTCTGCTTGAAGACGCTATGCAATCG
GGCCAGAATTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17581.02 Da        Isoelectric Point: 7.5659

>AT59996 WP_000649312.1 NZ_CP014035:2890582-2891049 [Vibrio fluvialis]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Download         Length: 468 bp

>AT59996 NZ_CP014035:2890582-2891049 [Vibrio fluvialis]
ATGAAAGCATATCACACATACAGTGCTGTAGACGTTGCATGGAGCTTGCTTAAGCATGCGAAAGAGCAAGGTAAATGCTT
CTCCAATTTGCAGCTACAAAAACTTACCTATGTTTGCCACGGTTTATCATTGGCACACTTCCAGCGTCCTCTTGTTGTGG
ATGACGTATTTGCTTGGAAATTTGGTCCCGTAGTTCCTTCTGTCTATTTTCGCTTTAAATCGTATGGCAGTAACGTGATC
ACCGAACAATGTGATGTGGTGTTAGATCATGAAAGTGAATCTATTGTCAAAGATGTAGTATCACAACTGGGGCATTTAAC
CGGCCCGCAGCTTGTAGATCTGACTCACCGTGAGGGTAGTCCATGGCATCAAGTATGGGATGGCACACATCAAAAAGTGA
TCCCTGACCATTTGATTCAAGCTCATTACACTCAGATCAAACAATCAGGGCGAACAGCTAGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8LPQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8LPP8

References