Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 661172..661731 Replicon chromosome
Accession NZ_CP014035
Organism Vibrio fluvialis strain FDAARGOS_104

Toxin (Protein)


Gene name relE Uniprot ID A0A0X8LL63
Locus tag AL536_RS33615 Protein ID WP_061056297.1
Coordinates 661417..661731 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Q2N1Z8
Locus tag AL536_RS33610 Protein ID WP_055466056.1
Coordinates 661172..661429 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL536_RS33585 656523..657422 + 900 WP_004725079.1 flagellar hook-associated protein FlgL -
AL536_RS33590 657434..658474 + 1041 WP_061056294.1 hypothetical protein -
AL536_RS33595 659241..660362 + 1122 WP_061056295.1 hypothetical protein -
AL536_RS33600 660359..660481 + 123 WP_081094754.1 DUF3265 domain-containing protein -
AL536_RS33605 660548..661024 + 477 WP_061056296.1 hypothetical protein -
AL536_RS33610 661172..661429 + 258 WP_055466056.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL536_RS33615 661417..661731 + 315 WP_061056297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL536_RS33620 662093..662368 - 276 WP_020329945.1 hypothetical protein -
AL536_RS33625 662564..662935 - 372 WP_020329946.1 helix-turn-helix transcriptional regulator -
AL536_RS33630 663089..663922 + 834 WP_061056298.1 SDR family oxidoreductase -
AL536_RS33635 664001..664528 - 528 WP_061056299.1 copper resistance protein NlpE -
AL536_RS33640 664665..664952 - 288 WP_024373222.1 hypothetical protein -
AL536_RS33645 665027..666019 - 993 WP_020329950.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11958.96 Da        Isoelectric Point: 4.8604

>T59995 WP_061056297.1 NZ_CP014035:661417-661731 [Vibrio fluvialis]
MAEIIWTDPALSDLNDIAEYIALENVAAAKQLVQTIFAKVERLENFPESGRIPPELVHLSYRELVVNPCRIFYKFDGAKV
FILFVMRSERDLRKFLLGMSSPLE

Download         Length: 315 bp

>T59995 NZ_CP014035:661417-661731 [Vibrio fluvialis]
ATGGCTGAAATAATCTGGACGGATCCTGCGTTATCTGACCTTAATGATATTGCTGAATACATCGCACTTGAAAATGTCGC
AGCTGCAAAGCAATTGGTTCAAACGATCTTCGCTAAAGTTGAACGCCTCGAAAATTTCCCCGAATCGGGTCGTATTCCGC
CCGAACTTGTACATCTCAGTTATCGTGAGTTGGTCGTGAACCCATGCCGTATTTTCTATAAATTCGACGGCGCTAAAGTG
TTTATTCTGTTTGTGATGCGTTCTGAGAGAGATTTGCGCAAGTTCCTGTTGGGCATGTCATCGCCTTTGGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9659.20 Da        Isoelectric Point: 8.5255

>AT59995 WP_055466056.1 NZ_CP014035:661172-661429 [Vibrio fluvialis]
MKVELVTSLKRQATKILADLRSTKEPVLITEHGKPSAYLVDVEDYEFMQNRLAILEGIARGERAFADGKVVSHEEAKDKM
SKWLK

Download         Length: 258 bp

>AT59995 NZ_CP014035:661172-661429 [Vibrio fluvialis]
ATGAAAGTAGAACTCGTGACATCGCTCAAACGTCAAGCTACGAAGATCCTTGCTGATCTCCGCAGCACGAAAGAACCTGT
ACTCATTACTGAACATGGTAAACCGTCGGCGTATCTAGTTGATGTTGAGGATTATGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGCATTGCGCGGGGTGAGCGTGCATTCGCTGACGGTAAAGTGGTGAGCCACGAGGAAGCCAAGGACAAAATG
TCGAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8LL63

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q2N1Z8

References