Detailed information of TA system TA059993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-KacA/DUF1778(antitoxin)
• Location: 3294257..3295054
• Replicon: chromosome
• Accession: NZ_CP014031
• Organism: Hafnia paralvei strain FDAARGOS_158

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: A0A2A2MF97
• Locus tag: AL518_RS15045
• Protein ID: WP_008813541.1
• Coordinates: 3294257..3294781 (-)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: KacA
• Uniprot ID: -
• Locus tag: AL518_RS15050
• Protein ID: WP_061060037.1
• Coordinates: 3294785..3295054 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL518_RS15020	3290236..3291279	+	1044	WP_061060036.1	oxidoreductase	-
AL518_RS15025	3291411..3292409	+	999	WP_008813543.1	bile acid:sodium symporter	-
AL518_RS15040	3293077..3294075	-	999	WP_008813542.1	adenosine deaminase	-
AL518_RS15045	3294257..3294781	-	525	WP_008813541.1	N-acetyltransferase	Toxin
AL518_RS15050	3294785..3295054	-	270	WP_061060037.1	DUF1778 domain-containing protein	Antitoxin
AL518_RS15055	3295290..3296465	-	1176	WP_061060038.1	pyridoxal phosphate-dependent aminotransferase	-
AL518_RS15060	3296553..3298148	-	1596	WP_039186680.1	maltose/glucose-specific PTS transporter subunit IIBC	-
AL518_RS15065	3298430..3299461	+	1032	WP_020303739.1	Mal regulon transcriptional regulator MalI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (8-84)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19643.50 Da
• Isoelectric Point: 7.0494

>T59993 WP_008813541.1 NZ_CP014031:c3294781-3294257 [Hafnia paralvei]
MPDLAIEIFSNDVEYDFAHFDCGEESLNIFLTNHLARQHNARILRGYLLVTKEPKPKVVGYYTLSGSCFEKETLPSNTQK
RKVPYANVPSVTLGRLAIQKELQGQDWGTTLVTHAMKVIYHASLAVGIHGMFVDALNEKAKRFYLQLGFIALTGNNANSL
FYPTKSIEKLFEDE

Nucleotide

• Length: 525 bp

>T59993 NZ_CP014031:c3294781-3294257 [Hafnia paralvei]
ATGCCAGATCTCGCTATTGAGATTTTTTCGAACGACGTCGAATATGATTTTGCTCATTTCGACTGTGGTGAAGAATCTCT
CAATATATTCCTCACCAATCATCTTGCCCGCCAGCACAACGCTCGAATCTTACGGGGTTATTTGCTGGTCACCAAAGAGC
CAAAACCTAAAGTCGTAGGATATTACACGTTATCTGGCAGTTGCTTCGAGAAAGAAACGCTTCCCTCAAACACACAGAAA
CGGAAAGTACCTTACGCTAATGTGCCCAGCGTCACCTTGGGGCGACTGGCTATCCAAAAAGAGTTGCAGGGACAAGACTG
GGGAACAACGCTGGTAACTCATGCTATGAAAGTCATCTATCACGCGTCACTGGCGGTCGGCATCCATGGTATGTTTGTTG
ATGCCCTTAACGAAAAAGCCAAGCGGTTCTATCTTCAACTTGGTTTTATTGCGCTTACAGGCAATAACGCAAACTCGTTG
TTCTACCCAACAAAATCCATCGAAAAGCTGTTTGAAGACGAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10082.50 Da
• Isoelectric Point: 7.0162

>AT59993 WP_061060037.1 NZ_CP014031:c3295054-3294785 [Hafnia paralvei]
MSALKKQRIDLRLTDDDKSKIEEAAAMTNQTITQFMVASAAERAEEVIEQHRRLVLNDESWNLVMDAISNPPAPNSRLKR
ASKRLASME

Nucleotide

• Length: 270 bp

>AT59993 NZ_CP014031:c3295054-3294785 [Hafnia paralvei]
ATGTCCGCCCTAAAAAAACAACGTATCGATCTCAGACTCACCGATGATGACAAAAGCAAGATCGAAGAAGCGGCCGCAAT
GACCAACCAAACTATCACCCAGTTTATGGTTGCTAGCGCCGCTGAACGCGCAGAGGAAGTCATTGAGCAGCATCGTCGTC
TCGTTCTCAACGATGAGTCGTGGAATTTGGTGATGGACGCTATCAGCAATCCGCCAGCCCCGAACAGTCGGCTGAAACGA
GCATCGAAACGTCTAGCGAGCATGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A2A2MF97