Detailed information of TA system TA059984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2745175..2745806
• Replicon: chromosome
• Accession: NZ_CP014031
• Organism: Hafnia paralvei strain FDAARGOS_158

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AL518_RS12320
• Protein ID: WP_061059845.1
• Coordinates: 2745175..2745348 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AL518_RS12325
• Protein ID: WP_061059846.1
• Coordinates: 2745399..2745806 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL518_RS12290	2740309..2740581	+	273	WP_061059839.1	PerC family transcriptional regulator	-
AL518_RS12295	2740584..2741237	+	654	WP_061059840.1	phage N-6-adenine-methyltransferase	-
AL518_RS12300	2741234..2741986	+	753	WP_061059841.1	hypothetical protein	-
AL518_RS12305	2741994..2742371	+	378	WP_061059842.1	RusA family crossover junction endodeoxyribonuclease	-
AL518_RS12310	2742368..2743372	+	1005	WP_094189196.1	DUF968 domain-containing protein	-
AL518_RS12315	2743393..2744088	+	696	WP_061059844.1	hypothetical protein	-
AL518_RS12320	2745175..2745348	+	174	WP_061059845.1	type II toxin-antitoxin system HicA family toxin	Toxin
AL518_RS12325	2745399..2745806	+	408	WP_061059846.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AL518_RS12330	2745899..2746723	+	825	WP_061059847.1	hypothetical protein	-
AL518_RS12335	2746949..2747281	+	333	WP_046450008.1	phage holin, lambda family	-
AL518_RS12340	2747291..2747905	+	615	WP_061059848.1	glycoside hydrolase family 19 protein	-
AL518_RS12345	2747902..2748444	+	543	WP_061059849.1	hypothetical protein	-
AL518_RS12355	2748896..2749033	+	138	Protein_2341	HNH endonuclease	-
AL518_RS12360	2749215..2749709	+	495	WP_004092442.1	DUF1441 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2730674..2796805	66131

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6561.67 Da
• Isoelectric Point: 11.6500

>T59984 WP_061059845.1 NZ_CP014031:2745175-2745348 [Hafnia paralvei]
VKQSEFRRWLEAQGVEVSNGTNHLKLRLNGKRSVMPRHPSSEIKEPLRKAIIKQLGL

Nucleotide

• Length: 174 bp

>T59984 NZ_CP014031:2745175-2745348 [Hafnia paralvei]
GTGAAGCAAAGCGAGTTTCGAAGATGGCTCGAAGCTCAGGGGGTTGAGGTTTCAAATGGTACGAATCACTTGAAGCTAAG
ACTAAACGGGAAGCGAAGTGTAATGCCAAGGCATCCCAGCTCTGAGATAAAAGAGCCGCTAAGAAAAGCAATCATTAAGC
AGTTAGGATTGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15008.27 Da
• Isoelectric Point: 4.4949

>AT59984 WP_061059846.1 NZ_CP014031:2745399-2745806 [Hafnia paralvei]
MRYPVNLEPDSGGFFVSFPDIPEALTQGDGREDALSMALDALVTAFEFYFEDNRKVPLPSEVTGEFVDVPLSVASKVLML
NAFIDSSLTQTELANRMGVKKQEITRLFDLKHATKIDAIQKAMQALGKRLELQVI

Nucleotide

• Length: 408 bp

>AT59984 NZ_CP014031:2745399-2745806 [Hafnia paralvei]
ATGCGATATCCCGTAAATCTAGAACCAGACAGCGGCGGATTTTTCGTAAGCTTCCCAGATATACCGGAAGCACTAACACA
GGGCGATGGCCGCGAAGACGCGTTATCAATGGCGCTTGATGCTTTAGTTACGGCTTTTGAGTTCTATTTCGAAGATAACC
GGAAAGTACCGCTACCCAGTGAGGTAACAGGGGAGTTTGTTGATGTGCCGCTTAGTGTGGCCTCAAAAGTGCTTATGCTT
AATGCTTTTATTGATTCCAGCTTGACCCAAACCGAGCTGGCTAATCGCATGGGCGTCAAAAAACAAGAGATCACTCGGCT
ATTTGATCTAAAGCATGCGACTAAAATCGATGCAATTCAGAAAGCTATGCAGGCTCTCGGTAAGAGGTTAGAGCTCCAAG
TCATTTAG