Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2745175..2745806 Replicon chromosome
Accession NZ_CP014031
Organism Hafnia paralvei strain FDAARGOS_158

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AL518_RS12320 Protein ID WP_061059845.1
Coordinates 2745175..2745348 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AL518_RS12325 Protein ID WP_061059846.1
Coordinates 2745399..2745806 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL518_RS12290 2740309..2740581 + 273 WP_061059839.1 PerC family transcriptional regulator -
AL518_RS12295 2740584..2741237 + 654 WP_061059840.1 phage N-6-adenine-methyltransferase -
AL518_RS12300 2741234..2741986 + 753 WP_061059841.1 hypothetical protein -
AL518_RS12305 2741994..2742371 + 378 WP_061059842.1 RusA family crossover junction endodeoxyribonuclease -
AL518_RS12310 2742368..2743372 + 1005 WP_094189196.1 DUF968 domain-containing protein -
AL518_RS12315 2743393..2744088 + 696 WP_061059844.1 hypothetical protein -
AL518_RS12320 2745175..2745348 + 174 WP_061059845.1 type II toxin-antitoxin system HicA family toxin Toxin
AL518_RS12325 2745399..2745806 + 408 WP_061059846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AL518_RS12330 2745899..2746723 + 825 WP_061059847.1 hypothetical protein -
AL518_RS12335 2746949..2747281 + 333 WP_046450008.1 phage holin, lambda family -
AL518_RS12340 2747291..2747905 + 615 WP_061059848.1 glycoside hydrolase family 19 protein -
AL518_RS12345 2747902..2748444 + 543 WP_061059849.1 hypothetical protein -
AL518_RS12355 2748896..2749033 + 138 Protein_2341 HNH endonuclease -
AL518_RS12360 2749215..2749709 + 495 WP_004092442.1 DUF1441 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2730674..2796805 66131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-63)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6561.67 Da        Isoelectric Point: 11.6500

>T59984 WP_061059845.1 NZ_CP014031:2745175-2745348 [Hafnia paralvei]
VKQSEFRRWLEAQGVEVSNGTNHLKLRLNGKRSVMPRHPSSEIKEPLRKAIIKQLGL

Download         Length: 174 bp

>T59984 NZ_CP014031:2745175-2745348 [Hafnia paralvei]
GTGAAGCAAAGCGAGTTTCGAAGATGGCTCGAAGCTCAGGGGGTTGAGGTTTCAAATGGTACGAATCACTTGAAGCTAAG
ACTAAACGGGAAGCGAAGTGTAATGCCAAGGCATCCCAGCTCTGAGATAAAAGAGCCGCTAAGAAAAGCAATCATTAAGC
AGTTAGGATTGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15008.27 Da        Isoelectric Point: 4.4949

>AT59984 WP_061059846.1 NZ_CP014031:2745399-2745806 [Hafnia paralvei]
MRYPVNLEPDSGGFFVSFPDIPEALTQGDGREDALSMALDALVTAFEFYFEDNRKVPLPSEVTGEFVDVPLSVASKVLML
NAFIDSSLTQTELANRMGVKKQEITRLFDLKHATKIDAIQKAMQALGKRLELQVI

Download         Length: 408 bp

>AT59984 NZ_CP014031:2745399-2745806 [Hafnia paralvei]
ATGCGATATCCCGTAAATCTAGAACCAGACAGCGGCGGATTTTTCGTAAGCTTCCCAGATATACCGGAAGCACTAACACA
GGGCGATGGCCGCGAAGACGCGTTATCAATGGCGCTTGATGCTTTAGTTACGGCTTTTGAGTTCTATTTCGAAGATAACC
GGAAAGTACCGCTACCCAGTGAGGTAACAGGGGAGTTTGTTGATGTGCCGCTTAGTGTGGCCTCAAAAGTGCTTATGCTT
AATGCTTTTATTGATTCCAGCTTGACCCAAACCGAGCTGGCTAATCGCATGGGCGTCAAAAAACAAGAGATCACTCGGCT
ATTTGATCTAAAGCATGCGACTAAAATCGATGCAATTCAGAAAGCTATGCAGGCTCTCGGTAAGAGGTTAGAGCTCCAAG
TCATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References