Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2294651..2295242 Replicon chromosome
Accession NZ_CP014031
Organism Hafnia paralvei strain FDAARGOS_158

Toxin (Protein)


Gene name Hha Uniprot ID G9Y5B5
Locus tag AL518_RS10395 Protein ID WP_004091739.1
Coordinates 2294651..2294854 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q9EVH1
Locus tag AL518_RS10400 Protein ID WP_008814252.1
Coordinates 2294868..2295242 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL518_RS10365 2289887..2290225 + 339 WP_004091732.1 P-II family nitrogen regulator -
AL518_RS10370 2290259..2291548 + 1290 WP_008814256.1 ammonium transporter AmtB -
AL518_RS10375 2291612..2292472 - 861 WP_008814255.1 acyl-CoA thioesterase II -
AL518_RS10380 2292785..2293303 + 519 WP_061059720.1 YbaY family lipoprotein -
AL518_RS10385 2293362..2293694 - 333 WP_008814253.1 MGMT family protein -
AL518_RS10395 2294651..2294854 - 204 WP_004091739.1 hemolysin expression modulator Hha Toxin
AL518_RS10400 2294868..2295242 - 375 WP_008814252.1 Hha toxicity modulator TomB Antitoxin
AL518_RS10405 2295759..2295899 - 141 WP_020303633.1 type B 50S ribosomal protein L36 -
AL518_RS10410 2295899..2296171 - 273 WP_004091742.1 type B 50S ribosomal protein L31 -
AL518_RS10415 2296332..2299484 - 3153 WP_039188527.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8119.38 Da        Isoelectric Point: 5.8346

>T59983 WP_004091739.1 NZ_CP014031:c2294854-2294651 [Hafnia paralvei]
MTKIDYLMRLRKCTTLDTLERVIEKNKYELSDDELETFYSAADHRLAELTMNKLYDKIPAEVWKYVR

Download         Length: 204 bp

>T59983 NZ_CP014031:c2294854-2294651 [Hafnia paralvei]
ATGACTAAAATTGATTACCTGATGCGTTTGCGTAAGTGCACTACCTTAGACACTCTCGAACGCGTGATTGAAAAAAATAA
GTATGAACTTTCCGACGATGAGCTAGAGACCTTCTACTCTGCGGCAGATCACCGTCTGGCAGAGCTAACGATGAACAAGC
TATATGACAAGATCCCAGCGGAAGTGTGGAAGTATGTACGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14447.17 Da        Isoelectric Point: 4.4776

>AT59983 WP_008814252.1 NZ_CP014031:c2295242-2294868 [Hafnia paralvei]
MDEYTSYQHDITELKYLCNMLYNQGMDVLSDSHHGWVNDPTAVDNLQLNELNEHIANFGLTFKIKYPNASELTEILDEYL
DETYSLFSNYSINEPELKKWLKAKGRILRYLAGEKTTSALNFNL

Download         Length: 375 bp

>AT59983 NZ_CP014031:c2295242-2294868 [Hafnia paralvei]
ATGGATGAATATACGTCTTATCAGCACGATATTACGGAGCTGAAATATCTATGTAATATGTTGTACAATCAAGGAATGGA
TGTTCTGAGCGATAGCCATCATGGCTGGGTCAACGACCCAACAGCAGTGGACAATCTACAACTAAATGAATTAAACGAAC
ATATTGCAAATTTTGGTTTAACATTCAAGATTAAGTATCCAAATGCTTCAGAATTAACTGAAATATTAGATGAGTATCTT
GACGAAACATACAGTCTGTTTAGTAATTACAGCATCAACGAACCAGAACTTAAAAAATGGCTTAAAGCAAAAGGCCGTAT
TTTGCGTTATTTAGCGGGTGAAAAAACCACATCTGCATTAAATTTTAACCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G9Y5B5

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q9EVH1

References