Detailed information of TA system TA059982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 2144025..2144844
• Replicon: chromosome
• Accession: NZ_CP014031
• Organism: Hafnia paralvei strain FDAARGOS_158

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: AL518_RS09725
• Protein ID: WP_004110819.1
• Coordinates: 2144587..2144844 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AL518_RS09720
• Protein ID: WP_061059678.1
• Coordinates: 2144025..2144576 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL518_RS09690	2140434..2141045	+	612	WP_061059674.1	hypothetical protein	-
AL518_RS20935	2141283..2141702	-	420	WP_174705392.1	tyrosine-type recombinase/integrase	-
AL518_RS09700	2141787..2142116	-	330	WP_048797655.1	hypothetical protein	-
AL518_RS09705	2142547..2142798	-	252	WP_096080403.1	hypothetical protein	-
AL518_RS09710	2142926..2143672	-	747	WP_061060425.1	class I SAM-dependent methyltransferase	-
AL518_RS20940	2143687..2144001	-	315	WP_174705374.1	hypothetical protein	-
AL518_RS09720	2144025..2144576	-	552	WP_061059678.1	N-acetyltransferase	Antitoxin
AL518_RS09725	2144587..2144844	-	258	WP_004110819.1	YjhX family toxin	Toxin
AL518_RS20825	2145120..2145260	-	141	Protein_1834	aldo/keto reductase	-
AL518_RS09735	2145575..2146705	+	1131	WP_061060426.1	GGDEF domain-containing protein	-
AL518_RS09740	2147382..2148209	+	828	WP_008814450.1	SDR family oxidoreductase	-
AL518_RS09745	2148290..2149345	+	1056	WP_039188389.1	NAD(P)-dependent alcohol dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (46-122)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T59982 WP_004110819.1 NZ_CP014031:c2144844-2144587 [Hafnia paralvei]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T59982 NZ_CP014031:c2144844-2144587 [Hafnia paralvei]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTTATTAAGTCCGTCAACGGGCAACCCTACCGTATCAATACCACCGGGCTGAACAACGTCCGCGCA
CAACTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20178.02 Da
• Isoelectric Point: 6.4015

>AT59982 WP_061059678.1 NZ_CP014031:c2144576-2144025 [Hafnia paralvei]
MTNPSLTFHVASEGDTDDILDVEARAFGYSKEANLVADLLNDESTYPMLSLLARHNGKAVGHILFTRATFNGEPDSPMMH
LLAPLAVVPEYQGVGIGGLLIQRGIEHLKAAGGKAVFVLGHETYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
QPLQRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59982 NZ_CP014031:c2144576-2144025 [Hafnia paralvei]
ATGACAAACCCCAGCCTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAGCCCGCGCTTT
CGGCTACAGCAAAGAGGCCAATCTGGTGGCCGATTTACTTAACGATGAGAGCACCTACCCGATGTTATCGCTGCTGGCCC
GGCATAACGGTAAGGCGGTTGGGCATATTTTATTTACCCGCGCGACGTTCAATGGGGAGCCTGACTCGCCAATGATGCAC
CTTCTAGCTCCGCTGGCGGTGGTGCCTGAATATCAGGGCGTTGGCATAGGCGGATTACTTATCCAACGCGGTATTGAGCA
TCTGAAAGCCGCAGGAGGCAAGGCGGTATTTGTTCTGGGACATGAAACCTACTACCCGAGACATGGATTTGAGCCATGTG
CCGGAGATAAAGGCTATCCGGCACCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCT
CAGCCGTTGCAGCGAACGGGACAGATACAGTGCGCCCGAGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2