Detailed information of TA system TA059981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1693055..1693622
• Replicon: chromosome
• Accession: NZ_CP014031
• Organism: Hafnia paralvei strain FDAARGOS_158

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AL518_RS07700
• Protein ID: WP_105375245.1
• Coordinates: 1693488..1693622 (-)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G9YED8
• Locus tag: AL518_RS07695
• Protein ID: WP_004097419.1
• Coordinates: 1693055..1693465 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL518_RS07670	1688606..1689643	+	1038	WP_008815242.1	LacI family DNA-binding transcriptional regulator	-
AL518_RS07675	1689851..1691311	+	1461	WP_039184955.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
AL518_RS07680	1691571..1692029	+	459	WP_039184820.1	ribonuclease N	-
AL518_RS07685	1692035..1692313	+	279	WP_004097415.1	barstar family protein	-
AL518_RS07690	1692393..1692950	-	558	WP_039184825.1	ribosome-associated protein	-
AL518_RS07695	1693055..1693465	-	411	WP_004097419.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AL518_RS07700	1693488..1693622	-	135	WP_105375245.1	type II toxin-antitoxin system HicA family toxin	Toxin
AL518_RS07705	1694009..1695349	+	1341	WP_008815237.1	metalloprotease PmbA	-
AL518_RS07715	1696537..1696929	+	393	WP_061059544.1	cytochrome b562	-
AL518_RS07720	1696932..1697450	+	519	WP_020303530.1	cytochrome b/b6 domain-containing protein	-
AL518_RS07725	1697501..1698607	-	1107	WP_061059545.1	transglutaminase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-44)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4901.75 Da
• Isoelectric Point: 11.9239

>T59981 WP_105375245.1 NZ_CP014031:c1693622-1693488 [Hafnia paralvei]
ILKRVKGSHHHFTHPNKTGLVTIPHPKKDLPANTVKSIRQQAGL

Nucleotide

• Length: 135 bp

>T59981 NZ_CP014031:c1693622-1693488 [Hafnia paralvei]
ATCCTTAAAAGGGTGAAGGGAAGCCATCATCACTTCACTCACCCCAACAAAACGGGGCTAGTGACGATTCCTCATCCTAA
AAAAGATCTCCCCGCCAATACCGTAAAAAGCATCCGGCAACAGGCTGGGCTTTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14951.18 Da
• Isoelectric Point: 4.5106

>AT59981 WP_004097419.1 NZ_CP014031:c1693465-1693055 [Hafnia paralvei]
MLYPIAIESGDQHHAYGVTVPDLPGCFSAGDTLDEAIANAKQAIISHIELLVEMEADFPMPSKIEDLSNKAEYQEYIWAI
VEVDVTRLMGGAEKINVTLPKSLIARIDRVVALHPEYKSRSGFLAQAALEQVTVIK

Nucleotide

• Length: 411 bp

>AT59981 NZ_CP014031:c1693465-1693055 [Hafnia paralvei]
ATGCTTTATCCCATTGCTATTGAATCCGGAGATCAACACCATGCTTACGGTGTAACCGTGCCTGATTTACCGGGGTGTTT
CTCTGCCGGTGATACGCTCGATGAAGCGATAGCTAACGCCAAGCAAGCAATCATTAGTCATATTGAATTGCTGGTTGAAA
TGGAAGCCGATTTTCCAATGCCATCAAAAATCGAAGATTTATCAAACAAAGCTGAATATCAGGAATACATCTGGGCTATC
GTCGAGGTTGATGTTACTCGCCTCATGGGCGGCGCAGAAAAGATTAACGTCACGCTCCCTAAGTCATTGATTGCCAGAAT
CGATCGCGTCGTTGCCTTACATCCTGAATATAAAAGCCGATCCGGTTTTTTAGCTCAGGCTGCGCTCGAACAGGTAACAG
TGATAAAATAG

Structures

Antitoxin

• AlphaFold DB: G9YED8