Detailed information of TA system TA059978

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4068511..4069165
• Replicon: chromosome
• Accession: NZ_CP014030
• Organism: Citrobacter sp. FDAARGOS_156 strain FDAARGOS_155

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AL515_RS19975
• Protein ID: WP_048213165.1
• Coordinates: 4068511..4068918 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A6N6K0R3
• Locus tag: AL515_RS19980
• Protein ID: WP_005123351.1
• Coordinates: 4068899..4069165 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL515_RS19955	4064412..4066145	-	1734	WP_061068519.1	single-stranded-DNA-specific exonuclease RecJ	-
AL515_RS19960	4066151..4066864	-	714	WP_048213163.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AL515_RS19965	4066888..4067784	-	897	WP_005123354.1	site-specific tyrosine recombinase XerD	-
AL515_RS19970	4067898..4068419	+	522	WP_048213164.1	flavodoxin FldB	-
AL515_RS19975	4068511..4068918	-	408	WP_048213165.1	protein YgfX	Toxin
AL515_RS19980	4068899..4069165	-	267	WP_005123351.1	FAD assembly factor SdhE	Antitoxin
AL515_RS19985	4069421..4070401	+	981	WP_048213166.1	tRNA-modifying protein YgfZ	-
AL515_RS19990	4070492..4071151	-	660	WP_003026947.1	hemolysin III family protein	-
AL515_RS19995	4071315..4071626	-	312	WP_048213167.1	N(4)-acetylcytidine aminohydrolase	-
AL515_RS20000	4071679..4072407	+	729	WP_061068520.1	MurR/RpiR family transcriptional regulator	-
AL515_RS20005	4072528..4073961	+	1434	WP_061068521.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15940.86 Da
• Isoelectric Point: 10.9468

>T59978 WP_048213165.1 NZ_CP014030:c4068918-4068511 [Citrobacter sp. FDAARGOS_156]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVCAPWMIKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQQVKQG

Nucleotide

• Length: 408 bp

>T59978 NZ_CP014030:c4068918-4068511 [Citrobacter sp. FDAARGOS_156]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCACAGTGGCTCTCTCTGCTCATTCATGGGCTGGTTGCGGT
ATTCATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGTTGGTGCTGCTCTCTCTGGTGGTGTTTGATAGCG
TACGCAGTCAGCGTCGCATTAACGCTTGTCAGGGAGAGATTAGACTGTTAATGGACGGTCGCCTGCGCTGGCAGGGGCAA
GAGTGGTCTATCGTTTGTGCACCCTGGATGATTAAAACGGGCATGATGCTGCGTTTGCGTTCAGATGCGGGAAAACGTCA
GCATTTGTGGCTGGCAGCGGACAGCATGGATGACGCTGAGTGGCGGGATTTGCGGCGGTTAATGCTGCAACAGGTAAAGC
AGGGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10642.16 Da
• Isoelectric Point: 5.1700

>AT59978 WP_005123351.1 NZ_CP014030:c4069165-4068899 [Citrobacter sp. FDAARGOS_156]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT59978 NZ_CP014030:c4069165-4068899 [Citrobacter sp. FDAARGOS_156]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTGGACATCTCTATCATGCCGTT
TTTTGAACATGAGTATGACAACTTAAGTGACGAAGAAAAACGCATCTTTATCCGTCTGCTGGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGAGCAGTTGGAGCAGATGGTGCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6N6K0R3