59968

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1515721..1516341 Replicon chromosome
Accession NZ_CP014030
Organism Citrobacter sp. FDAARGOS_156 strain FDAARGOS_155

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AL515_RS07365 Protein ID WP_002892050.1
Coordinates 1515721..1515939 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag AL515_RS07370 Protein ID WP_003021733.1
Coordinates 1515967..1516341 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL515_RS07330 1511070..1511681 + 612 WP_061067435.1 membrane protein -
AL515_RS07335 1511764..1512117 + 354 WP_061067436.1 DUF1428 family protein -
AL515_RS07340 1512172..1513725 - 1554 Protein_1364 EAL domain-containing protein -
AL515_RS07345 1513914..1514174 + 261 WP_005125189.1 type B 50S ribosomal protein L31 -
AL515_RS07350 1514176..1514316 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
AL515_RS07355 1514394..1514864 - 471 WP_040232692.1 YlaC family protein -
AL515_RS07360 1514981..1515532 - 552 WP_061067437.1 maltose O-acetyltransferase -
AL515_RS07365 1515721..1515939 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AL515_RS07370 1515967..1516341 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
AL515_RS07375 1516830..1519979 - 3150 WP_048212411.1 efflux RND transporter permease AcrB -
AL515_RS07380 1520002..1521195 - 1194 WP_061067438.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T59968 WP_002892050.1 NZ_CP014030:c1515939-1515721 [Citrobacter sp. FDAARGOS_156]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T59968 NZ_CP014030:c1515939-1515721 [Citrobacter sp. FDAARGOS_156]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGCTGTCAAACAATTGACACGCTTGAACGTGT
TATTGAGAAAAATAAATATGAATTGTCTGACAATGAACTGGCTGTATTTTACTCAGCCGCCGATCATCGTCTTGCTGAAT
TGACAATGAATAAGCTCTACGACAAGATCCCAACATCTGTTTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT59968 WP_003021733.1 NZ_CP014030:c1516341-1515967 [Citrobacter sp. FDAARGOS_156]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT59968 NZ_CP014030:c1516341-1515967 [Citrobacter sp. FDAARGOS_156]
ATGGATGAATACTCACCGAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGCAACCATGGTTGGGTAAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATTGATGAATACCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGTATTAATACGCAGGATCTACAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTCAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References