59967

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 868630..869146 Replicon chromosome
Accession NZ_CP014030
Organism Citrobacter sp. FDAARGOS_156 strain FDAARGOS_155

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag AL515_RS04265 Protein ID WP_003839578.1
Coordinates 868862..869146 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag AL515_RS04260 Protein ID WP_003839576.1
Coordinates 868630..868872 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL515_RS04240 863645..864778 + 1134 WP_061067121.1 amidohydrolase/deacetylase family metallohydrolase -
AL515_RS04245 864762..865880 + 1119 WP_061067122.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
AL515_RS04250 865877..866617 + 741 WP_048212847.1 KDGP aldolase family protein -
AL515_RS04255 866639..868552 + 1914 WP_061067123.1 BglG family transcription antiterminator -
AL515_RS04260 868630..868872 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AL515_RS04265 868862..869146 + 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL515_RS04270 869150..869614 - 465 WP_005134199.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AL515_RS04275 869721..871859 - 2139 WP_061067124.1 anaerobic ribonucleoside-triphosphate reductase -
AL515_RS04280 872268..873920 - 1653 WP_061067125.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T59967 WP_003839578.1 NZ_CP014030:868862-869146 [Citrobacter sp. FDAARGOS_156]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T59967 NZ_CP014030:868862-869146 [Citrobacter sp. FDAARGOS_156]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT59967 WP_003839576.1 NZ_CP014030:868630-868872 [Citrobacter sp. FDAARGOS_156]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT59967 NZ_CP014030:868630-868872 [Citrobacter sp. FDAARGOS_156]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References