Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2009921..2010578 Replicon chromosome
Accession NZ_CP014029
Organism Klebsiella aerogenes strain FDAARGOS_152

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag AL511_RS09925 Protein ID WP_015369792.1
Coordinates 2009921..2010331 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag AL511_RS09930 Protein ID WP_015369791.1
Coordinates 2010312..2010578 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL511_RS09905 2005920..2007653 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
AL511_RS09910 2007659..2008372 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AL511_RS09915 2008395..2009291 - 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
AL511_RS09920 2009392..2009913 + 522 WP_015369793.1 flavodoxin FldB -
AL511_RS09925 2009921..2010331 - 411 WP_015369792.1 protein YgfX Toxin
AL511_RS09930 2010312..2010578 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
AL511_RS09935 2010802..2011785 + 984 WP_015369790.1 tRNA-modifying protein YgfZ -
AL511_RS09940 2011884..2012543 - 660 WP_008806429.1 hemolysin III family protein -
AL511_RS09945 2012708..2013019 - 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
AL511_RS09950 2013070..2013798 + 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
AL511_RS09955 2013918..2015351 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T59960 WP_015369792.1 NZ_CP014029:c2010331-2009921 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T59960 NZ_CP014029:c2010331-2009921 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTAATCGACTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAGCCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT59960 WP_015369791.1 NZ_CP014029:c2010578-2010312 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT59960 NZ_CP014029:c2010578-2010312 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References