Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1672277..1673057 Replicon chromosome
Accession NZ_CP014029
Organism Klebsiella aerogenes strain FDAARGOS_152

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag AL511_RS08210 Protein ID WP_015370123.1
Coordinates 1672728..1673057 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AL511_RS08205 Protein ID WP_127175768.1
Coordinates 1672277..1672675 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL511_RS08155 1667736..1668143 + 408 WP_032710459.1 hypothetical protein -
AL511_RS08160 1668216..1668443 + 228 WP_015370132.1 hypothetical protein -
AL511_RS08165 1668443..1668688 + 246 WP_032710460.1 hypothetical protein -
AL511_RS08170 1668746..1669582 + 837 WP_061069201.1 hypothetical protein -
AL511_RS08175 1669676..1669909 + 234 WP_015370129.1 DUF905 domain-containing protein -
AL511_RS08180 1670007..1670825 + 819 WP_015370128.1 DUF945 domain-containing protein -
AL511_RS08185 1670825..1671079 + 255 WP_071647618.1 hypothetical protein -
AL511_RS08190 1671096..1671575 + 480 WP_032710462.1 antirestriction protein -
AL511_RS08195 1671587..1672066 + 480 WP_015370126.1 DNA repair protein RadC -
AL511_RS08200 1672087..1672308 + 222 WP_015370125.1 DUF987 domain-containing protein -
AL511_RS08205 1672277..1672675 + 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AL511_RS08210 1672728..1673057 + 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
AL511_RS08215 1673463..1673564 + 102 Protein_1574 preprotein translocase -
AL511_RS08220 1673723..1674523 - 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
AL511_RS08225 1674699..1675235 - 537 WP_015370121.1 dihydrofolate reductase family protein -
AL511_RS08230 1675435..1675797 - 363 WP_015370120.1 cupin domain-containing protein -
AL511_RS08235 1675873..1676691 - 819 WP_032706441.1 AraC family transcriptional regulator -
AL511_RS08240 1677019..1677246 - 228 WP_071647620.1 DUF1272 domain-containing protein -
AL511_RS26530 1677537..1677689 + 153 WP_157844032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1647577..1676691 29114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T59959 WP_015370123.1 NZ_CP014029:1672728-1673057 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T59959 NZ_CP014029:1672728-1673057 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT59959 WP_127175768.1 NZ_CP014029:1672277-1672675 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT59959 NZ_CP014029:1672277-1672675 [Klebsiella aerogenes]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References