Detailed information of TA system TA059949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 5381123..5381803
• Replicon: chromosome
• Accession: NZ_CP014028
• Organism: Achromobacter xylosoxidans strain FDAARGOS_150

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AL509_RS24490
• Protein ID: WP_006386381.1
• Coordinates: 5381123..5381308 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AL509_RS24495
• Protein ID: WP_006386380.1
• Coordinates: 5381384..5381803 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL509_RS24480	5377262..5378665	+	1404	WP_104414229.1	dihydrolipoyl dehydrogenase	-
AL509_RS24485	5378837..5380876	-	2040	WP_104414230.1	pyruvate, phosphate dikinase	-
AL509_RS24490	5381123..5381308	+	186	WP_006386381.1	type II toxin-antitoxin system HicA family toxin	Toxin
AL509_RS24495	5381384..5381803	+	420	WP_006386380.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AL509_RS24500	5381894..5383312	-	1419	WP_006386379.1	argininosuccinate lyase	-
AL509_RS24505	5383522..5384853	+	1332	WP_049053945.1	mechanosensitive ion channel	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-94)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7058.16 Da
• Isoelectric Point: 10.6654

>T59949 WP_006386381.1 NZ_CP014028:5381123-5381308 [Achromobacter xylosoxidans]
MKYSEFKKWLERQGAVFVAHRSGSSHFRVTLNGATTIFPYHGSKEMGKHLEHEIKKQLGLK

Nucleotide

• Length: 186 bp

>T59949 NZ_CP014028:5381123-5381308 [Achromobacter xylosoxidans]
ATGAAATACAGCGAATTCAAAAAATGGCTTGAGCGGCAAGGAGCGGTTTTTGTTGCGCATCGTTCCGGAAGCAGCCATTT
TCGGGTCACGTTGAACGGCGCCACGACGATCTTTCCGTACCATGGCTCCAAGGAAATGGGTAAACACCTTGAACATGAAA
TCAAGAAGCAGCTCGGATTGAAATAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15506.81 Da
• Isoelectric Point: 4.9597

>AT59949 WP_006386380.1 NZ_CP014028:5381384-5381803 [Achromobacter xylosoxidans]
MLTYPFTLTLDSNRTWLVRFPDIPEALTVGDDEQEAAINAREALEAALEIYFDARRPIPLPSPVSAGQASVTLPALITSK
VFLSNEMIQQGVRKAELARRMGVHMPQVDRLLDVRHASRIEQVESALEQLGRRLEVSLA

Nucleotide

• Length: 420 bp

>AT59949 NZ_CP014028:5381384-5381803 [Achromobacter xylosoxidans]
ATGCTGACCTATCCGTTCACCCTGACGCTTGATTCCAATCGCACCTGGCTCGTTCGATTTCCAGATATTCCGGAAGCGTT
GACGGTTGGTGACGACGAGCAAGAGGCCGCGATCAACGCCAGGGAAGCGCTTGAGGCTGCGCTGGAAATCTACTTTGACG
CGCGCCGCCCCATTCCGCTGCCGTCGCCCGTATCGGCGGGGCAGGCGTCGGTGACCTTGCCGGCACTGATCACCAGCAAG
GTGTTCCTGTCCAACGAGATGATCCAGCAAGGTGTGCGCAAGGCGGAGTTGGCTCGCCGCATGGGCGTGCACATGCCGCA
AGTGGATCGTCTGCTGGATGTGCGGCACGCATCCCGGATCGAGCAGGTCGAGTCGGCGTTGGAGCAGCTTGGGCGGCGCC
TGGAGGTGTCGCTGGCCTGA