Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3961492..3962065 Replicon chromosome
Accession NZ_CP014028
Organism Achromobacter xylosoxidans strain FDAARGOS_150

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AL509_RS17995 Protein ID WP_054439446.1
Coordinates 3961688..3962065 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AL509_RS17990 Protein ID WP_054471260.1
Coordinates 3961492..3961701 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL509_RS17970 3956899..3957687 - 789 WP_049054627.1 helix-turn-helix transcriptional regulator -
AL509_RS17975 3957786..3958712 + 927 WP_020924995.1 DMT family transporter -
AL509_RS17980 3958725..3959543 - 819 WP_104413926.1 AAC(3) family N-acetyltransferase -
AL509_RS17985 3959695..3961368 + 1674 WP_006388972.1 energy-dependent translational throttle protein EttA -
AL509_RS17990 3961492..3961701 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AL509_RS17995 3961688..3962065 + 378 WP_054439446.1 type II toxin-antitoxin system VapC family toxin Toxin
AL509_RS18000 3962133..3962666 + 534 WP_054480708.1 isochorismatase family protein -
AL509_RS18005 3962857..3963081 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
AL509_RS18010 3963211..3963468 - 258 WP_006388977.1 cell division topological specificity factor MinE -
AL509_RS18015 3963472..3964287 - 816 WP_006388978.1 septum site-determining protein MinD -
AL509_RS18020 3964476..3965393 - 918 WP_104413927.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13906.15 Da        Isoelectric Point: 6.3738

>T59948 WP_054439446.1 NZ_CP014028:3961688-3962065 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPYLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTRDKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T59948 NZ_CP014028:3961688-3962065 [Achromobacter xylosoxidans]
ATGATCCTGGTTGACACTTCCATCTGGATAGATCATTTATCCGACGGCGAGCCATATCTGGTGCGCTTGCTGGAGGAAGA
AAGTGTATTGATGCACCCGTTCATCGCGGGTGAATTGGCGCTTGGTTCGTTGGGCCGGCGTGACGTTGTATTGGGTGCGA
TGTCGCTATTGCCTCAAGTCGTGCGTGCGAGTCATGACGAAGTCATGCACTTTCTTCATAGCGAGAGATTGTTTGGAAAG
GGCATTGGTTATGTGGATTTACACTTGTTGGCGTCCACGCGACTGACACCTGGCGCGGCGCTATGGACCAGGGACAAACG
GCTGCAGGCACTCGCCACCACCTTGAGCCTGGCGGTTGATCCCCCGAGATATCATTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT59948 WP_054471260.1 NZ_CP014028:3961492-3961701 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT59948 NZ_CP014028:3961492-3961701 [Achromobacter xylosoxidans]
GTGCGTACGACTGTGACGCTCGATGACGACCTGCTCGAATTGGCCCGTACCTATACGGGCGTCCAGGAGACATCGGCGCT
CGTAACGCGAGCGCTGACCCAGCTCGTGCAGAAAGAGGCCGCGAAGCGGTTGGCCAAGCTTGGTGGTAGTTCGCCCAAGT
TGAAGCCTATCCCGCGGCGGCAGACGGAAACCTGCAATGATCCTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References