Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 501365..501977 Replicon chromosome
Accession NZ_CP014027
Organism Streptococcus pyogenes strain FDAARGOS_149

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag AL510_RS02505 Protein ID WP_010922665.1
Coordinates 501642..501977 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag AL510_RS02500 Protein ID WP_002988079.1
Coordinates 501365..501652 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL510_RS02470 496542..497525 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
AL510_RS02475 497529..498458 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
AL510_RS02480 498506..499021 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
AL510_RS02485 499056..499484 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
AL510_RS02490 499931..500704 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
AL510_RS02500 501365..501652 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
AL510_RS02505 501642..501977 + 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL510_RS02510 502129..502311 + 183 WP_011285716.1 integrase -
AL510_RS02520 502645..503082 + 438 WP_076639988.1 site-specific integrase -
AL510_RS02525 503202..503594 - 393 WP_002982716.1 30S ribosomal protein S9 -
AL510_RS02530 503615..504061 - 447 WP_002982710.1 50S ribosomal protein L13 -
AL510_RS02535 504279..504485 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
AL510_RS02540 504482..504988 - 507 WP_002988070.1 hypothetical protein -
AL510_RS02545 505124..505984 - 861 WP_002982687.1 DegV family protein -
AL510_RS02550 506081..506599 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T59947 WP_010922665.1 NZ_CP014027:501642-501977 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T59947 NZ_CP014027:501642-501977 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT59947 WP_002988079.1 NZ_CP014027:501365-501652 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT59947 NZ_CP014027:501365-501652 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References