Detailed information of TA system TA059946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3473291..3474108
• Replicon: chromosome
• Accession: NZ_CP014026
• Organism: Morganella morganii strain FDAARGOS_172

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: AL531_RS16925
• Protein ID: WP_015422406.1
• Coordinates: 3473602..3474108 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: J7TDK6
• Locus tag: AL531_RS16920
• Protein ID: WP_004236533.1
• Coordinates: 3473291..3473599 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL531_RS16895	3468598..3468804	-	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-
AL531_RS16900	3468912..3469904	-	993	WP_004236539.1	inner membrane protein YhjD	-
AL531_RS16905	3470316..3470705	-	390	WP_004236536.1	DUF1090 domain-containing protein	-
AL531_RS16910	3470895..3471737	+	843	WP_004236535.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
AL531_RS16915	3471807..3473159	+	1353	WP_004236534.1	glutathione-disulfide reductase	-
AL531_RS16920	3473291..3473599	+	309	WP_004236533.1	DUF1778 domain-containing protein	Antitoxin
AL531_RS16925	3473602..3474108	+	507	WP_015422406.1	GNAT family N-acetyltransferase	Toxin
AL531_RS19205	3474116..3474362	-	247	Protein_3256	hypothetical protein	-
AL531_RS16930	3474359..3474880	-	522	WP_015422407.1	isopentenyl-diphosphate Delta-isomerase	-
AL531_RS16935	3475008..3475310	-	303	WP_004236529.1	ABC transporter substrate-binding protein	-
AL531_RS16940	3475520..3476635	-	1116	WP_004236528.1	molybdenum cofactor guanylyltransferase MobA	-
AL531_RS16945	3476838..3477107	+	270	WP_004240741.1	YihD family protein	-
AL531_RS16950	3477107..3478102	+	996	WP_004236526.1	serine/threonine protein kinase	-
AL531_RS16955	3478121..3478744	+	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18565.43 Da
• Isoelectric Point: 9.9508

>T59946 WP_015422406.1 NZ_CP014026:3473602-3474108 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T59946 NZ_CP014026:3473602-3474108 [Morganella morganii]
TTGAACTTAACGGCACCGGAACCCTTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCA
TTGGCTGAAAACCCGCGCATTGCAAAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAA
TGGCCTATTATGCATTATCGACAGGCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAA
ATTCCGGTTATCCTGCCGGGACGTCTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGA
TGCCGCACTGCGGGTCTTGCAGGCGGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCA
GACGTTTTTATGAGCATACCGGTTTTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAG
CTGGCAACCGGCATCTATTCTGAATAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11499.15 Da
• Isoelectric Point: 8.6397

>AT59946 WP_004236533.1 NZ_CP014026:3473291-3473599 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT59946 NZ_CP014026:3473291-3473599 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Structures

Antitoxin

• AlphaFold DB: J7TDK6