Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 4668228..4669267 | Replicon | chromosome |
| Accession | NZ_CP014025 | ||
| Organism | Pseudomonas fulva strain FDAARGOS_167 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | AL527_RS21195 | Protein ID | WP_027913401.1 |
| Coordinates | 4668692..4669267 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A0S4I9D6 |
| Locus tag | AL527_RS21190 | Protein ID | WP_027913402.1 |
| Coordinates | 4668228..4668695 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL527_RS21170 | 4663862..4664677 | - | 816 | WP_080671980.1 | TniB family NTP-binding protein | - |
| AL527_RS21175 | 4664759..4666636 | - | 1878 | WP_023532294.1 | DDE-type integrase/transposase/recombinase | - |
| AL527_RS21180 | 4666639..4667277 | - | 639 | WP_033728311.1 | heteromeric transposase endonuclease subunit TnsA | - |
| AL527_RS21185 | 4667356..4668015 | + | 660 | Protein_4122 | ATP-binding protein | - |
| AL527_RS21190 | 4668228..4668695 | + | 468 | WP_027913402.1 | helix-turn-helix domain-containing protein | Antitoxin |
| AL527_RS21195 | 4668692..4669267 | + | 576 | WP_027913401.1 | PIN domain-containing protein | Toxin |
| AL527_RS21200 | 4669447..4670223 | + | 777 | WP_027913400.1 | alpha/beta hydrolase | - |
| AL527_RS21205 | 4670223..4671020 | + | 798 | WP_028686766.1 | SDR family oxidoreductase | - |
| AL527_RS21210 | 4671149..4672060 | + | 912 | WP_027913398.1 | LysR family transcriptional regulator | - |
| AL527_RS21215 | 4672346..4674187 | - | 1842 | WP_028686767.1 | amidohydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | algC | 4595039..4835845 | 240806 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21955.26 Da Isoelectric Point: 5.5909
>T59945 WP_027913401.1 NZ_CP014025:4668692-4669267 [Pseudomonas fulva]
MRHSPFTVIYDACVLYPAPLRDLLMHLALTGAYRARWSEQIHDEWTRNVLRNRPDVSETQLYRTVGLMNRAIPDSLVNDY
EPLVQGLDLPDEDDRHVLAAAIKCGASVIVTYNLKDFPAEILKRFEIEALHPDVFLSDIWDLDQAAVLKAVQKQRAALNN
PVYSPRELLDILLKQRLPETVKHLSNYELLI
MRHSPFTVIYDACVLYPAPLRDLLMHLALTGAYRARWSEQIHDEWTRNVLRNRPDVSETQLYRTVGLMNRAIPDSLVNDY
EPLVQGLDLPDEDDRHVLAAAIKCGASVIVTYNLKDFPAEILKRFEIEALHPDVFLSDIWDLDQAAVLKAVQKQRAALNN
PVYSPRELLDILLKQRLPETVKHLSNYELLI
Download Length: 576 bp
>T59945 NZ_CP014025:4668692-4669267 [Pseudomonas fulva]
ATGAGGCACTCACCTTTTACAGTTATCTACGACGCCTGCGTGCTTTATCCAGCACCATTGCGTGACCTATTGATGCATCT
GGCTCTGACTGGCGCGTATCGCGCGCGCTGGTCCGAGCAAATCCACGATGAATGGACACGAAACGTGTTAAGAAACCGTC
CCGACGTGTCAGAAACACAACTTTATCGCACAGTCGGACTCATGAATCGGGCGATTCCTGACTCTCTGGTAAATGACTAC
GAGCCACTTGTGCAGGGGCTTGACCTTCCAGACGAAGACGATAGACACGTCTTGGCAGCAGCGATCAAATGTGGCGCCTC
GGTGATTGTCACGTACAACCTCAAAGATTTTCCGGCCGAGATTCTGAAACGTTTTGAGATCGAGGCGTTGCATCCCGATG
TATTCCTCTCCGACATCTGGGACCTTGATCAGGCAGCTGTGCTCAAGGCCGTCCAGAAGCAGCGCGCAGCCCTTAACAAT
CCGGTTTACTCACCCCGCGAGCTGCTGGACATCCTCCTCAAGCAGCGGCTCCCAGAGACCGTCAAGCACCTCTCGAACTA
CGAGCTGCTGATCTAA
ATGAGGCACTCACCTTTTACAGTTATCTACGACGCCTGCGTGCTTTATCCAGCACCATTGCGTGACCTATTGATGCATCT
GGCTCTGACTGGCGCGTATCGCGCGCGCTGGTCCGAGCAAATCCACGATGAATGGACACGAAACGTGTTAAGAAACCGTC
CCGACGTGTCAGAAACACAACTTTATCGCACAGTCGGACTCATGAATCGGGCGATTCCTGACTCTCTGGTAAATGACTAC
GAGCCACTTGTGCAGGGGCTTGACCTTCCAGACGAAGACGATAGACACGTCTTGGCAGCAGCGATCAAATGTGGCGCCTC
GGTGATTGTCACGTACAACCTCAAAGATTTTCCGGCCGAGATTCTGAAACGTTTTGAGATCGAGGCGTTGCATCCCGATG
TATTCCTCTCCGACATCTGGGACCTTGATCAGGCAGCTGTGCTCAAGGCCGTCCAGAAGCAGCGCGCAGCCCTTAACAAT
CCGGTTTACTCACCCCGCGAGCTGCTGGACATCCTCCTCAAGCAGCGGCTCCCAGAGACCGTCAAGCACCTCTCGAACTA
CGAGCTGCTGATCTAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17035.46 Da Isoelectric Point: 4.9896
>AT59945 WP_027913402.1 NZ_CP014025:4668228-4668695 [Pseudomonas fulva]
MTTADLAQAILPDEKAITAAIESSRQIAAFVSTKLDTQRIELVDEAQQRQTVELPTFALRLLGDILNELALGNTVKVVPI
HAELTTQEGADMLNVSRPHLVKLLDEGLIPHTKTGSHRRVKFTDLMAYKADRDKASQAAMDELAAQAQELNMGYQ
MTTADLAQAILPDEKAITAAIESSRQIAAFVSTKLDTQRIELVDEAQQRQTVELPTFALRLLGDILNELALGNTVKVVPI
HAELTTQEGADMLNVSRPHLVKLLDEGLIPHTKTGSHRRVKFTDLMAYKADRDKASQAAMDELAAQAQELNMGYQ
Download Length: 468 bp
>AT59945 NZ_CP014025:4668228-4668695 [Pseudomonas fulva]
ATGACTACCGCCGATCTCGCTCAAGCCATCCTTCCAGATGAAAAAGCGATCACCGCGGCTATTGAGTCAAGCCGCCAGAT
TGCCGCGTTCGTCTCAACCAAGTTGGATACTCAGCGCATTGAGTTGGTAGATGAAGCCCAGCAACGGCAGACTGTTGAAC
TGCCAACGTTCGCGCTCAGATTGCTTGGCGACATACTCAACGAGCTGGCCTTGGGCAACACCGTAAAGGTGGTGCCTATC
CATGCGGAACTGACCACCCAGGAGGGCGCCGATATGCTCAACGTCTCGCGTCCTCACTTGGTCAAGCTGCTGGATGAGGG
GCTAATCCCACACACCAAAACCGGCAGCCACCGCCGTGTAAAATTTACTGACCTAATGGCCTACAAGGCCGATCGTGATA
AAGCAAGCCAGGCCGCCATGGATGAACTGGCTGCACAAGCCCAAGAACTTAATATGGGCTATCAATGA
ATGACTACCGCCGATCTCGCTCAAGCCATCCTTCCAGATGAAAAAGCGATCACCGCGGCTATTGAGTCAAGCCGCCAGAT
TGCCGCGTTCGTCTCAACCAAGTTGGATACTCAGCGCATTGAGTTGGTAGATGAAGCCCAGCAACGGCAGACTGTTGAAC
TGCCAACGTTCGCGCTCAGATTGCTTGGCGACATACTCAACGAGCTGGCCTTGGGCAACACCGTAAAGGTGGTGCCTATC
CATGCGGAACTGACCACCCAGGAGGGCGCCGATATGCTCAACGTCTCGCGTCCTCACTTGGTCAAGCTGCTGGATGAGGG
GCTAATCCCACACACCAAAACCGGCAGCCACCGCCGTGTAAAATTTACTGACCTAATGGCCTACAAGGCCGATCGTGATA
AAGCAAGCCAGGCCGCCATGGATGAACTGGCTGCACAAGCCCAAGAACTTAATATGGGCTATCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|