Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3933873..3934524 Replicon chromosome
Accession NZ_CP014024
Organism Providencia stuartii strain FDAARGOS_145

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag AL507_RS18475 Protein ID WP_004927064.1
Coordinates 3933873..3934076 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag AL507_RS18480 Protein ID WP_004927067.1
Coordinates 3934156..3934524 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL507_RS18450 3929750..3930088 + 339 WP_004927053.1 P-II family nitrogen regulator -
AL507_RS18455 3930099..3931382 + 1284 WP_014656764.1 ammonium transporter AmtB -
AL507_RS18460 3931619..3932485 - 867 WP_004927058.1 acyl-CoA thioesterase II -
AL507_RS18465 3932809..3933267 + 459 WP_004927062.1 YbaY family lipoprotein -
AL507_RS18475 3933873..3934076 - 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
AL507_RS18480 3934156..3934524 - 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
AL507_RS18485 3935092..3936429 - 1338 WP_004927077.1 murein transglycosylase D -
AL507_RS18490 3936508..3937263 - 756 WP_040132835.1 hydroxyacylglutathione hydrolase -
AL507_RS18495 3937297..3938022 + 726 WP_061064703.1 methyltransferase domain-containing protein -
AL507_RS18500 3938101..3938571 - 471 WP_014656762.1 ribonuclease HI -
AL507_RS18505 3938626..3939387 + 762 WP_004927092.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T59943 WP_004927064.1 NZ_CP014024:c3934076-3933873 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T59943 NZ_CP014024:c3934076-3933873 [Providencia stuartii]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACTATCGATACACTTGAGCGTGTTATTGAGAAAAATAA
GTATGAGCTTTCTGAAGATGAGTTAGAATTGTTCTATTCAGCTGCTGACCATCGCCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATCCCTGCATCGGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT59943 WP_004927067.1 NZ_CP014024:c3934524-3934156 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT59943 NZ_CP014024:c3934524-3934156 [Providencia stuartii]
ATGGATGAATATTCACCCAAAAATTATGATATATCTGAGTTAAAATACTTGTGTAACAGTTTGAATCGAGAAGCAATGTT
AAGCTTACAGAAAACTAATACACACTGGGTCAATGATTTAAGTTCACCACAAAGTGCTAGACTTAATGAACTCATTGAAC
ATATTGCAGCCTTCGTGTGGCAATTTAAGATAAAATATCCCAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GATGAGACTTATGATTTATTCGGAAGCCCTGTAATAACTCTAAGTGAAATTATTGACTGGCAGAGCATGAATCAAAATCT
AGTTTCCGTACTTGATGATGATTTAAAGTGCCCTGCAAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References