59942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3049627..3051356 Replicon chromosome
Accession NZ_CP014024
Organism Providencia stuartii strain FDAARGOS_145

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag AL507_RS14625 Protein ID WP_061064542.1
Coordinates 3049627..3050271 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID B2PV44
Locus tag AL507_RS14630 Protein ID WP_004924122.1
Coordinates 3050283..3051356 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL507_RS14610 3047113..3047943 + 831 WP_014657166.1 formate dehydrogenase accessory sulfurtransferase FdhD -
AL507_RS14615 3048046..3048825 - 780 WP_004924128.1 hypothetical protein -
AL507_RS14620 3049058..3049627 + 570 WP_061064541.1 DUF4433 domain-containing protein -
AL507_RS14625 3049627..3050271 + 645 WP_061064542.1 DUF4433 domain-containing protein Toxin
AL507_RS14630 3050283..3051356 + 1074 WP_004924122.1 macro domain-containing protein Antitoxin
AL507_RS14635 3051458..3052822 - 1365 WP_061064543.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
AL507_RS14640 3052922..3054571 - 1650 WP_004924116.1 membrane protein insertase YidC -
AL507_RS14645 3054574..3054834 - 261 WP_014657163.1 membrane protein insertion efficiency factor YidD -
AL507_RS14650 3054798..3055157 - 360 WP_004924110.1 ribonuclease P protein component -
AL507_RS14655 3055179..3055322 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 24924.57 Da        Isoelectric Point: 7.1693

>T59942 WP_061064542.1 NZ_CP014024:3049627-3050271 [Providencia stuartii]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHLSPNWVTIGNTDLISRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLTAIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPIEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF

Download         Length: 645 bp

>T59942 NZ_CP014024:3049627-3050271 [Providencia stuartii]
ATGGCGTATATGAACCTAAACCCAGAAAAAGCACTTATCTGGAGAATAACCCATCGTCAGAATATTCCTTGGCTTTTTGC
CAATGGCTTATATGCAGGAAATAGTGAACATCTGTCGCCTAATTGGGTGACTATTGGCAATACAGACCTAATTAGCCGCC
GTAATCAACGTCATGTACCTATTCAACCAAATGGCGTACTTAATGATTATGTGCCTTTCTATTTTACGCCTTTTTCTCCA
ATGATGTATAATATTTACACAGGTCGTGGTGGGGTGCGAAAAGTTCCCAATGATGATATTATCATCTTGGTTTCCAGCAT
GTATAAAATAGCCGCCCTAAAGATACCTTTTGTATTCACCGATCGTCATGCATATCCTGTGACGTCTCAGTTTTATAACC
AGTTAACAGATCTAACGGCGATAGATTGGGCTTTACTACAGCAGCGTAATTTTCACCGTGACCCTGATGACCCTGAAAAA
GTTGAAAGGTATCAAGCGGAAGCTTTAATTTATAAACATGTTCCTATAGAGGCTCTATTGGGTGCTGTTTGTTACACAAA
AGAAACCCAGCTAGAACTTCAAGCAAAAGCCAGCCAACTTGAGATTCATTTAGATATCCATTGCATTCCAAACTGGTACT
TTTAA

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40685.18 Da        Isoelectric Point: 7.8185

>AT59942 WP_004924122.1 NZ_CP014024:3050283-3051356 [Providencia stuartii]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLFDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDLQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLKNPLNLKFEAKNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPSIESLLEG
IRQWPAGDRWAQRKLRLFDSSKLELALNHLKQIPFYS

Download         Length: 1074 bp

>AT59942 NZ_CP014024:3050283-3051356 [Providencia stuartii]
ATGATAGAATTTACTCAGGGTAATTTGTTAGAAGCTGACGTAGAAGCGCTCGTTAATACCGTCAATACTGTTGGTGTTAT
GGGTAAAGGGATCGCGTTAATGTTTAAAGAGCGCTTTCCCGCCAATATGGCTGCATATGCTAAAGCATGTAAAACACATG
AAGTGCAAACTGGAAAAATGTTTGTCACTGAAACAGGTGAGCTCATGGGCCCTCGTTGGATTGTTAATTTCCCAACAAAG
CAGCATTGGCGAGCAAAATCTCAAATTCAGTGGATTATTGATGGCTTGTTTGATTTACGTAATTTCATTGAAGAAAATCA
TGTTAAATCTATTGCGATCCCGCCATTAGGTGCTGGTAATGGTGGCCTCAATTGGGATGACGTCAAACCTCATATTGTGG
AAATATTAGGTGATCTTCAAAACGTAAAAATTATTGTTTATGAGCCAATAGCAAAATATCAAAATGTTGCTAAACCAAAA
GGCGTTGAAAAACTGACACCTGCTCGTGCCTTAATCGCAGAACTTATCCGTCGCTATTGGGTTATGGGGATGGATTGTAG
CCTATTGGAAATACAGAAGTTAGCTTGGTTTTTAGAACGTACAATAGAGGCTGAAGGGCTAAAAAATCCATTAAACCTAA
AGTTTGAAGCCAAAAACTATGGCCCCTACGCCGATAAGTTACGCCACTTACTAAACGGACTAGATGGAAGCTACCTCAAG
AGTGAAAAACGGATTAGTGATTGTAGTCCATTGGATGTAATTTGGTTTAATGATGATAAACGCGCTACGATTGAGCTGTA
TTTAAAAACCGAAGCAAAAGACTATTTATCCGCACTAGAGAAGACAACAAAGCTTATTGATGGGTTCGAATCTCCTTTTG
GGATAGAGCTTCTCTCCACTGTAGACTGGTTACTGTACAAAAAACAATCTTCACCTAGTATTGAATCCTTACTTGAAGGA
ATACGCCAGTGGCCAGCAGGGGATAGATGGGCGCAACGTAAACTTAGGTTATTTGACTCGAGTAAGTTAGAACTTGCATT
AAATCATTTGAAACAAATACCGTTCTATAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B2PV44

References