Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 203433..204090 Replicon chromosome
Accession NZ_CP014024
Organism Providencia stuartii strain FDAARGOS_145

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag AL507_RS00900 Protein ID WP_036941148.1
Coordinates 203680..204090 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag AL507_RS00895 Protein ID WP_004921708.1
Coordinates 203433..203699 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL507_RS00880 198464..201340 + 2877 WP_004921716.1 aminomethyl-transferring glycine dehydrogenase -
AL507_RS00885 201559..202179 - 621 WP_004921714.1 HD domain-containing protein -
AL507_RS00890 202191..203180 - 990 WP_004921711.1 tRNA-modifying protein YgfZ -
AL507_RS00895 203433..203699 + 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
AL507_RS00900 203680..204090 + 411 WP_036941148.1 membrane protein Toxin
AL507_RS00905 204136..204654 - 519 WP_014656387.1 flavodoxin FldB -
AL507_RS00910 204817..205740 + 924 WP_004921697.1 site-specific tyrosine recombinase XerD -
AL507_RS00915 205760..206464 + 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AL507_RS00920 206470..208203 + 1734 WP_061063825.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T59941 WP_036941148.1 NZ_CP014024:203680-204090 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T59941 NZ_CP014024:203680-204090 [Providencia stuartii]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACTCAGCTTTTTTCAACCTGTGCTCATGGGGTAGTCGGCTT
TATTCTATTGGTCGCACCATGGGCGCCAGGGAATTCAATGGTGTGGTTGCCGCTGTTAGTGATTGTGATTGCTAGCTGGG
CAAAAAGCCAAAAAAGCATCAGCAAAATCAAAGGGACTGCGGTACTGGTTAATGGCAATAAAGTCCAATGGAAAAAGAAT
GAGTGGAGTATCGTTAAGCAACCTTGGTGTAGCCGTGTGGGGGTATTATTGACACTCAGTGCCTTACAAGGTAAGCCACA
GAAGATCCGTTTATGGGTTGCAAAAGATGCCTTATCAGAAGAGAGCTGGCGTAATTTAAACCAACTATTACTGCAATATC
CTGATATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT59941 WP_004921708.1 NZ_CP014024:203433-203699 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT59941 NZ_CP014024:203433-203699 [Providencia stuartii]
ATGGATATAGAGAATAAAGCAAGAATTCATTGGGCTTGCCGTCGTGGTATGCGTGAGTTGGATATTTCCATCATGCCATT
CTTTGAATATGAATATGAAGGACTTTCTGACAAGGACAAACGTACTTTTGTTCGTTTACTTGAGTGTGCAGACCCTGATC
TGTTTAACTGGTTAATGAATCATGGGCGCCCAGACGACGATGAGTTGTTTGGTATGGTTAAATTGATTCAGGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References