Detailed information of TA system TA059940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 997141..997659
• Replicon: chromosome
• Accession: NZ_CP014023
• Organism: Staphylococcus lugdunensis strain FDAARGOS_143

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: AL501_RS04915
• Protein ID: WP_062077888.1
• Coordinates: 997141..997353 (-)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A853V130
• Locus tag: AL501_RS04920
• Protein ID: WP_002492098.1
• Coordinates: 997366..997659 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL501_RS04895	992517..993875	-	1359	WP_062077884.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
AL501_RS04900	993893..994963	-	1071	WP_062077886.1	D-alanine--D-alanine ligase	-
AL501_RS04905	995319..996509	+	1191	WP_002461205.1	rod shape-determining protein RodA	-
AL501_RS04910	996913..997050	-	138	WP_002461206.1	hypothetical protein	-
AL501_RS04915	997141..997353	-	213	WP_062077888.1	heavy-metal-associated domain-containing protein	Toxin
AL501_RS04920	997366..997659	-	294	WP_002492098.1	copper-sensing transcriptional repressor CsoR	Antitoxin
AL501_RS04925	997825..999309	+	1485	WP_002478972.1	cardiolipin synthase	-
AL501_RS04930	999431..1000072	+	642	WP_002492092.1	HD domain-containing protein	-
AL501_RS04935	1000456..1001331	-	876	WP_002461212.1	membrane protein insertase YidC	-
AL501_RS04940	1001421..1002059	-	639	WP_002461213.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (6-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-90)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8146.21 Da
• Isoelectric Point: 4.1677

>T59940 WP_062077888.1 NZ_CP014023:c997353-997141 [Staphylococcus lugdunensis]
VEKRLIYITNVTSEDDLKYLRTRLLEMIGVNEVVINFDERAVNVTFETPTNLNALEKEIYDVGYHAIDDL

Nucleotide

• Length: 213 bp

>T59940 NZ_CP014023:c997353-997141 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAGTGAAGACGACTTGAAATACTTACGAACAAGGTTATTAGAGAT
GATCGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTTGAAACACCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGTTGGCTATCATGCTATAGATGATTTATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11177.85 Da
• Isoelectric Point: 6.6367

>AT59940 WP_002492098.1 NZ_CP014023:c997659-997366 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Nucleotide

• Length: 294 bp

>AT59940 NZ_CP014023:c997659-997366 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTGGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAAATGCTAAAAGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A853V130