Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 985750..986267 Replicon chromosome
Accession NZ_CP014023
Organism Staphylococcus lugdunensis strain FDAARGOS_143

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag AL501_RS04855 Protein ID WP_002461192.1
Coordinates 985750..986100 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag AL501_RS04860 Protein ID WP_002461193.1
Coordinates 986097..986267 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL501_RS04835 982672..983442 - 771 WP_002461188.1 RNA polymerase sigma factor SigB -
AL501_RS04840 983417..983896 - 480 WP_012990787.1 anti-sigma B factor RsbW -
AL501_RS04845 983898..984224 - 327 WP_002461190.1 anti-sigma factor antagonist -
AL501_RS04850 984315..985316 - 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
AL501_RS04855 985750..986100 - 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AL501_RS04860 986097..986267 - 171 WP_002461193.1 hypothetical protein Antitoxin
AL501_RS04865 986354..987502 - 1149 WP_062077878.1 alanine racemase -
AL501_RS04870 987550..987942 - 393 WP_002461196.1 holo-ACP synthase -
AL501_RS04875 987954..988466 - 513 WP_062077880.1 PH domain-containing protein -
AL501_RS04880 988453..989967 - 1515 WP_062077882.1 PH domain-containing protein -
AL501_RS04885 989960..990442 - 483 WP_002492078.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T59939 WP_002461192.1 NZ_CP014023:c986100-985750 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T59939 NZ_CP014023:c986100-985750 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGCTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT59939 WP_002461193.1 NZ_CP014023:c986267-986097 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT59939 NZ_CP014023:c986267-986097 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTCCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References