Detailed information of TA system TA059938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 845679..846488
• Replicon: chromosome
• Accession: NZ_CP014023
• Organism: Staphylococcus lugdunensis strain FDAARGOS_143

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: AL501_RS04060
• Protein ID: WP_002458758.1
• Coordinates: 845679..845849 (-)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: AL501_RS04065
• Protein ID: WP_002458757.1
• Coordinates: 845889..846488 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL501_RS04035	840771..841394	-	624	WP_002477980.1	response regulator transcription factor	-
AL501_RS04040	841416..842528	-	1113	WP_060795476.1	GAF domain-containing sensor histidine kinase	-
AL501_RS04045	842696..843532	+	837	WP_002477978.1	RluA family pseudouridine synthase	-
AL501_RS04050	843597..844982	-	1386	WP_062077812.1	class II fumarate hydratase	-
AL501_RS04055	845110..845505	-	396	WP_037545575.1	hypothetical protein	-
AL501_RS04060	845679..845849	-	171	WP_002458758.1	hypothetical protein	Toxin
AL501_RS04065	845889..846488	-	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
AL501_RS04070	846654..847124	-	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
AL501_RS04075	847126..848268	-	1143	WP_103284502.1	tRNA epoxyqueuosine(34) reductase QueG	-
AL501_RS04080	848726..849451	-	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
AL501_RS04085	849444..850901	-	1458	WP_062077816.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T59938 WP_002458758.1 NZ_CP014023:c845849-845679 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T59938 NZ_CP014023:c845849-845679 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT59938 WP_002458757.1 NZ_CP014023:c846488-845889 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT59938 NZ_CP014023:c846488-845889 [Staphylococcus lugdunensis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATATTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2