Detailed information of TA system TA059937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /ImmA-HTH_19
• Location: 816888..817677
• Replicon: chromosome
• Accession: NZ_CP014023
• Organism: Staphylococcus lugdunensis strain FDAARGOS_143

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AL501_RS03885
• Protein ID: WP_062078785.1
• Coordinates: 817228..817677 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AL501_RS03880
• Protein ID: WP_062077454.1
• Coordinates: 816888..817214 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL501_RS03840	812469..812678	-	210	WP_062077784.1	hypothetical protein	-
AL501_RS03845	812702..812815	-	114	Protein_754	phage head-tail connector protein	-
AL501_RS03850	812828..813736	-	909	WP_062077786.1	hypothetical protein	-
AL501_RS03855	813754..814335	-	582	WP_062078781.1	DUF4355 domain-containing protein	-
AL501_RS03860	814538..814789	-	252	WP_062078783.1	hypothetical protein	-
AL501_RS03865	814800..816173	-	1374	WP_062077788.1	minor capsid protein	-
AL501_RS03870	816163..816474	-	312	WP_062077790.1	phage portal protein	-
AL501_RS03875	816505..816735	-	231	WP_062077792.1	helix-turn-helix transcriptional regulator	-
AL501_RS03880	816888..817214	+	327	WP_062077454.1	helix-turn-helix domain-containing protein	Antitoxin
AL501_RS03885	817228..817677	+	450	WP_062078785.1	ImmA/IrrE family metallo-endopeptidase	Toxin
AL501_RS03890	817810..818850	+	1041	WP_062077795.1	Abi family protein	-
AL501_RS03895	819014..820069	+	1056	WP_062077796.1	site-specific integrase	-
AL501_RS03940	821327..821881	-	555	WP_002458782.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	811073..821881	10808

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (31-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 17885.48 Da
• Isoelectric Point: 6.9587

>T59937 WP_062078785.1 NZ_CP014023:817228-817677 [Staphylococcus lugdunensis]
MRKYEELLSRNEHLMIKETNNLPYNLSGLTLDHYIFINSNHSKSKQLETLAEEIAHTQITYGDIRNQNNLLNRKYELKAR
RLSYEILMPLSEIIEAYKQGVQNMYELADFFEVSEGFVQQCIRHYKCKYGLEVKYKDYLIKFEPFRVCE

Nucleotide

• Length: 450 bp

>T59937 NZ_CP014023:817228-817677 [Staphylococcus lugdunensis]
TTGAGAAAATATGAAGAGTTATTAAGTAGAAACGAACACCTTATGATAAAAGAAACTAACAACTTACCTTATAACTTGAG
TGGTCTGACTTTAGATCATTATATTTTTATTAATAGCAATCATTCAAAGTCTAAACAACTTGAAACATTGGCTGAAGAAA
TAGCACATACACAAATTACATATGGCGATATTAGAAATCAAAATAATTTATTAAATCGAAAATACGAACTAAAGGCACGT
CGCTTATCATATGAAATTTTAATGCCTTTAAGTGAAATTATCGAGGCTTATAAGCAAGGAGTACAGAATATGTATGAACT
TGCTGATTTTTTTGAGGTTTCAGAAGGTTTTGTACAACAATGTATCAGGCATTATAAGTGTAAGTATGGATTGGAAGTTA
AATATAAGGATTACCTTATAAAGTTCGAACCGTTTAGAGTATGCGAATAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12397.01 Da
• Isoelectric Point: 6.9806

>AT59937 WP_062077454.1 NZ_CP014023:816888-817214 [Staphylococcus lugdunensis]
MCFSKRMKQSREKQGITLAELGKKIGKTEATVQRYESGNIKNLKNDTIESIANALNVNPAYLMGWIENKSQDNQKQFETL
AAHLDGELTDDQWNEVLKYAQYIIDKDK

Nucleotide

• Length: 327 bp

>AT59937 NZ_CP014023:816888-817214 [Staphylococcus lugdunensis]
ATGTGTTTTTCCAAAAGAATGAAACAGTCACGTGAGAAGCAAGGAATAACTTTAGCAGAACTTGGTAAAAAAATAGGTAA
AACTGAAGCAACTGTTCAAAGATATGAAAGTGGAAATATAAAAAATCTAAAAAATGACACTATAGAAAGCATTGCTAATG
CATTGAATGTCAATCCAGCATATTTAATGGGTTGGATAGAAAATAAAAGTCAAGATAATCAAAAGCAATTTGAAACATTA
GCAGCTCATTTAGATGGTGAACTCACCGATGATCAGTGGAATGAAGTTTTAAAATATGCTCAGTATATTATCGATAAAGA
TAAGTAA