Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2451605..2452140 Replicon chromosome
Accession NZ_CP014022
Organism Staphylococcus lugdunensis strain FDAARGOS_141

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag AL499_RS11495 Protein ID WP_002445368.1
Coordinates 2451817..2452140 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag AL499_RS11490 Protein ID WP_001058489.1
Coordinates 2451605..2451814 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL499_RS11455 2446861..2447145 + 285 WP_002461410.1 co-chaperone GroES -
AL499_RS11460 2447205..2448827 + 1623 WP_002461409.1 chaperonin GroEL -
AL499_RS11465 2448896..2450068 - 1173 WP_002492309.1 site-specific integrase -
AL499_RS11470 2450082..2450756 - 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
AL499_RS11475 2450929..2451147 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
AL499_RS11480 2451152..2451469 + 318 WP_002445364.1 helix-turn-helix domain-containing protein -
AL499_RS11485 2451466..2451612 + 147 WP_002445365.1 hypothetical protein -
AL499_RS11490 2451605..2451814 + 210 WP_001058489.1 hypothetical protein Antitoxin
AL499_RS11495 2451817..2452140 + 324 WP_002445368.1 DUF1474 family protein Toxin
AL499_RS11500 2452204..2453073 + 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
AL499_RS11505 2453087..2454796 + 1710 WP_002445371.1 DUF927 domain-containing protein -
AL499_RS11510 2455144..2455509 + 366 WP_002445372.1 hypothetical protein -
AL499_RS11515 2455523..2456164 + 642 WP_002492310.1 pathogenicity island protein -
AL499_RS11520 2456452..2456796 + 345 WP_002445374.1 hypothetical protein -
AL499_RS11525 2456810..2457043 + 234 WP_002492317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2443196..2460033 16837


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T59935 WP_002445368.1 NZ_CP014022:2451817-2452140 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T59935 NZ_CP014022:2451817-2452140 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT59935 WP_001058489.1 NZ_CP014022:2451605-2451814 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT59935 NZ_CP014022:2451605-2451814 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References